Recovery, Purification and Storage Recovery, Purification and Storage
Section 1: The new science of epigenetics and the sex-specific mechanisms of gene regulation 1. Overview of various perceptions of epigenetics 2. Sex differences in gene expression in the brain 3. Epigenetics of sex differences in the brain 4. Advances in studying epigenetics biomarkers of prognostic potential for clinical research, epigenetics of rRNA Genes 5. Single cell look at epigenetic inheritance mechanisms 6. Review of the epigenetics evolution 7. Epigenetics of human disease 8. Malignant transformation and epigenetics 9. The role of transposable elements in human disease Section 2: How is sex established? 10. Searching for sex in the genome 11. Concept of the sexome 12. Ovarian formation 13. How XX and XY supporting cells initiate sex determination Section 3: What is the role of the environment in shaping the phenome? 14. Early life environment and the epigenome 15. Mechanisms of transmission of sex-specific epigenetic changes to subsequent generations 16. Gene-environment interactions related to epigenetic and classical genetic mechanisms 17. Environmental epigenetics 18. The concept of the exposome Section 4: New concepts of the biology that produces deviations in sexual development, sexual dysphoria and homosexuality 19. The role of epigenetics in delineating the biological basis of human sexual orientation 20. The epigenetic factors that may canalize homosexuality 21. Molecular biology of sexualization of the brain Section 5: Commentary on the much-touted discipline of personalized medicine 22. Deciphering individual molecular biology to prevent, detect and treat human disease 23. Traditionally constructed large epidemiologic studies 24. Geneome sequencing and analysis at the expense of more useful large epidemiologic studies 25. Biological sex in the pursuit of personalized medicine 26. Underserved communities and personalized medicine 27. Value, pitfalls, and opportunities of pursuing personalized medicine Section 6: The integration of technology into the human body 28. The use of AI/technology to diagnose and treat disease 29. Cyborgs and the evolution of man + machine 30. Overview of the developments and achievements in orthotic and prosthetic technology 31. Use of brain implants to treat neurological problems 32. The Use of technology to augment the human competence 33. The fascinating concept of the post human 34. The future of human intelligence 35. Neural interface that will last a lifetime to generate neural prosthetic devices to possibly enhance brain function 36. Application of cyborg technology and theory to space travel by humans 37. Use of personalized medicine to supplement the lack of sex-specific information in the young field of space medicine Section 7: CRISPR-Cas9 technology 38. Problems/inadequacies/limitations of CRISPRP-Cas9 Genome Editing 39. iochemistry and Molecular Biology Education 40. First steps on making changes in mitochondrial DNA 41. Mitochondrial genetic manipulation 42. Strategy for manipulating the mitochondrial genome with cytidine deaminase toxin 43. The ethics and governance of genetic engineering
Dr. Marianne Legato, Professor Emerita of Clinical Medicine at Columbia University is an internationally known academic physician, author, lecturer, and specialist in gender-specific medicine. She is founding member of the International Society for Gender Medicine and also the founder and director of The Partnership for Gender-Specific Medicine at Columbia University and its next iteration, The Foundation for Gender-Specific Medicine. She has published extensively on gender and sex specific medicine, both scientifically and for the lay public. She is also the founding editor of the journal Gender Medicine, and the journal Gender and the Genome, published for the scientific community. In 1992, Dr. Legato won the American Heart Association's Blakeslee Award for the best book written for the lay public on cardiovascular disease. She is a practicing internist in New York City and has been listed each year in New York Magazine's Best Doctors since the feature's inception in 1993.
