Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies: Applications

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Wendy Fantl (Assistant Professor, Department of Urology and by-courtesy appointment in Obstetrics and Gynecology Stanford University, CA, USA)

Revealing Uncharted Biology with Single Cell Multiplex Proteomic Technologies

Applications

Wendy Fantl (Assistant Professor, Department of Urology and by-courtesy appointment in Obstetrics and Gynecology Stanford University, CA, USA)

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Paperback

Forthcoming
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English

Academic Press Inc
28 June 2024

Cellular biology (cytology)

Revealing Unchartered Biology with Single Intact Cells: Case Studies explores the path to research success, key projects, the role of techniques, the selection process, other alternatives considered, what other paths have led to dead ends, detailed protocols followed, and how the analysis of generated data allowed researchers to visualize unchartered biology. Focusing on the research journey that led to the publication of each article, the book's editors interviewed the researchers on the use of the Multiplex Single Cell technique and how it helped hone in on the biological quest. These methods can be expanded to a wide variety of research objectives.

In conclusion to each chapter, the authors critically review their process and provide suggestions of improvement or alternate techniques that could be employed. This book is the ideal reference for researchers new to the world of single-cell multiplex techniques. The discussion on failures encountered along the research path provides insights on how to avoid repeating the same errors.

Edited by: Wendy Fantl (Assistant Professor Department of Urology and by-courtesy appointment in Obstetrics and Gynecology Stanford University CA USA)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 235mm, Width: 191mm,
ISBN: 9780128222133
ISBN 10: 0128222131
Pages: 300
Publication Date: 28 June 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Forthcoming

1. Assessing global immune competence using CyTOF 2. Contributing to Cconsortia human tissue mapping efforts with multiplexed imaging 3. Novel single-cell technologies advance our mechanistic understanding of muscle stem cell function in skeletal muslce regeneration 4. Spatial quantification of cellular metabolism in tissues by metabolic regulome profiling 5. From bench to bedside: practical considerations for translational studies using single-cell mass cytometry 6. Developing predictive biomarkers for endometrial cancer immunotherapy with mass cytometry 7. Imaging mass cytometry in pre-clinical studies of lung cancer

Dr. Wendy Fantl is an assistant professor in the Department of Urology and by-courtesy appointment in Obstetrics and Gynecology Stanford University (CA, USA). Wendy received her BA in Biochemistry from the University of York (UK) and PhD in Protein Biochemistry from Rockefeller University (NY, USA) before becoming a post-doc and adjunct assistant professor at the University of California, San Francisco (CA, USA). Wendy has 16 years of experience working in Biotechnology and Pharmaceutical industries. Wendy’s passion is in the mechanistic understanding of intracellular signaling pathways, DNA damage and the host immune system and their role in malignancies with an “eye on the prize of a clinically translational endpoint. Her current interests are to apply multi-parametric single-cell technology platforms to identify disease-causing cell subpopulations in ovarian cancer and other malignancies.