Lipid Oxidation in Health and Disease

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Corinne M. Spickett (Aston University, Birmingham, UK) Henry Jay Forman (University of Southern California, Los Angeles, USA)

Lipid Oxidation in Health and Disease

Corinne M. Spickett (Aston University, Birmingham, UK), Henry Jay Forman (University of Southern California, Los Angeles, USA)

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English

CRC Press
14 October 2024

Endocrinology; Molecular biology; Cellular biology (cytology)

Series: Oxidative Stress and Disease

Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes.

Covering the diverse topics that contribute to research in this important field, this book explores:

The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids

Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

Edited by: Corinne M. Spickett (Aston University Birmingham UK), Henry Jay Forman (University of Southern California, Los Angeles, USA)
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 453g
ISBN: 9781032919867
ISBN 10: 1032919868
Series: Oxidative Stress and Disease
Pages: 440
Publication Date: 14 October 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Corinne M. Spickett is a reader at Aston University in Birmingham, UK. She has studied the analysis of phospholipid oxidation by electrospray mass spectrometry and the biological effects of oxidized lipids. More recently, she expanded her research to include analysis of protein oxidation and formation of lipoxidation products during inflammation, and has been developing label-free, semi-targeted approaches to their identification in biological samples. Henry Jay Forman is a distinguished professor of biochemistry and chemistry and founding faculty at the University of California, Merced. His expertise is in the areas of oxidative stress and signal transduction. His major research achievements are pioneering work in mitochondrial superoxide production, redox signaling, and mechanisms of induced resistance to oxidative stress.