Bile Acids and Their Receptors

Stefano Fiorucci, Eleonora Distrutti

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English

Springer Nature Switzerland AG
19 September 2020

Physiology; Endocrinology; Gastroenterology; Hepatology; Pharmacology

Series: Handbook of Experimental Pharmacology

Summary
Details

This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.

Edited by: Stefano Fiorucci, Eleonora Distrutti
Imprint: Springer Nature Switzerland AG
Country of Publication: Switzerland
Edition: 1st ed. 2019
Volume: 256
Dimensions: Height: 235mm, Width: 155mm,
Weight: 593g
ISBN: 9783030220075
ISBN 10: 3030220079
Series: Handbook of Experimental Pharmacology
Pages: 378
Publication Date: 19 September 2020
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active