Vitamin D in Childhood

From Biology to Clinical Practice

Chandra Sekhar Devulapalli

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English

Chandra Sekhar Devulapalli
09 September 2025

Clinical & internal medicine

This comprehensive pediatric vitamin D book offers an authoritative exploration of vitamin D's vital roles in child health, extending beyond bone mineralization to immunity, growth, and chronic disease prevention. It synthesizes cutting-edge research, clinical updates, and public health insights to guide optimization of vitamin D status in diverse pediatric populations. Beginning with foundational biology and determinants of vitamin D status, the book examines immunomodulatory effects in common pediatric conditions like respiratory infections, asthma, atopic dermatitis, autoimmune diseases, and fatigue. It critically evaluates observational and interventional evidence, emphasizing individualized approaches considering baseline status and disease phenotypes. Addressing diagnostic challenges and controversies over deficiency versus insufficiency, it provides practical supplementation guidance tailored to age, comorbidities, and region. The book highlights global epidemiology, policy successes, and ongoing disparities, stressing the need for culturally sensitive interventions. By surveying both mechanistic insights and applied strategies, it underscores the need to translate molecular discoveries into clinical care, while also assessing lifestyle, environmental, and sociocultural determinants that complicate prevention and treatment. Case examples and comparative perspectives enrich the discussion, situating vitamin D at the intersection of clinical medicine and population health. Furthermore, this work presents a multidisciplinary framework that integrates pediatric endocrinology, immunology, nutrition, and public health, fostering a holistic understanding crucial for advancing personalized interventions. It also addresses the implications of global demographic shifts, climate change, and evolving child health landscapes, underscoring the urgency of adaptive strategies in vitamin D research and policy. Future priorities include harmonizing definitions, conducting robust trials in vulnerable groups, exploring genetic influences, and assessing scalable interventions. It calls for collaborative clinical, research, and policy efforts to reduce inequities and improve child health worldwide. An essential resource for clinicians, researchers, and policymakers, this book bridges science and practice, charting a clear path to advance pediatric vitamin D health in the coming decade and beyond.

By: Chandra Sekhar Devulapalli
Imprint: Chandra Sekhar Devulapalli
Dimensions: Height: 216mm, Width: 140mm, Spine: 12mm
Weight: 240g
ISBN: 9788269434422
ISBN 10: 8269434426
Pages: 204
Publication Date: 09 September 2025
Audience: General/trade , ELT Advanced
Format: Paperback
Publisher's Status: Active

The author, Dr Chandra Sekhar Devulapalli, has made significant scholarly contributions to pediatric vitamin D research, forming the scientific foundation of this monograph through multiple peer-reviewed articles in reputable journals. His work explores vitamin D's role in child health, covering status assessment, supplementation, and clinical implications in diverse pediatric populations. Key publications include studies on vitamin D concentrations among native Norwegian adolescents and immigrant children, highlighting prevalent insufficiency and informing tailored public health strategies (Acta Paediatr, 2024). He has compared vitamin D intake and status among vegetarian, vegan, and omnivorous children, revealing dietary patterns that influence deficiency risk (Acta Paediatr, 2025). His work on vitamin D supplementation demonstrated its efficacy in reducing viral upper respiratory infections in children with low baseline levels (Acta Paediatr, 2025). A review on physical activity and vitamin D highlighted synergistic effects on bone health and fitness in pediatric cohorts (J Pediatr Endocrinol Metab, 2025). Devulapalli also investigated vitamin D's intersection with chronic conditions like asthma and immune-mediated deficiency, emphasizing clinical implications and diagnostic challenges (World J Pediatr, 2025). Other studies addressed hidden deficiency in overweight children and the modulatory role of vitamin D in atopic dermatitis and allergic rhinitis. His recently published article in Acta Paediatrica (2025) examined the paradox of rickets persisting despite ample sunlight, underscoring his continuing commitment to exploring complex pediatric vitamin D issues with significant public health impact. Additionally, his study on vitamin D deficiency and fatigue in children-published in World Journal of Pediatrics (2025)-highlighted a critical but often overlooked dimension of pediatric vitamin D insufficiency. Together, these publications demonstrate rigorous methodologies and synthesis of mechanistic and clinical evidence, advancing efforts to translate research into practical guidance. This impactful body of work substantially enhances the understanding of pediatric vitamin D and directly informs the comprehensive insights presented throughout this monograph.