The Systemic Effects of Advanced Cancer: A Textbook on Cancer-Associated Cachexia

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Swarnali Acharyya

The Systemic Effects of Advanced Cancer

A Textbook on Cancer-Associated Cachexia

Swarnali Acharyya

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English

Springer International Publishing AG
19 October 2022

Oncology; Immunology; Cellular biology (cytology)

This textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1.

Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise.

An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.

Edited by: Swarnali Acharyya
Imprint: Springer International Publishing AG
Country of Publication: Switzerland
Edition: 1st ed. 2022
Dimensions: Height: 254mm, Width: 178mm,
Weight: 605g
ISBN: 9783031072727
ISBN 10: 3031072723
Pages: 203
Publication Date: 19 October 2022
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Chapter 1: A systemic view of metastatic disease: inter-organ crosstalk and therapeutic implications PART I - Systemic Regulation in Metastatic Disease Chapter 2: Systemic Regulation of Metastatic Disease by Extracellular Vesicles and Particles Chapter 3: Bone Metastasis: Systemic Regulation and Impact on Host Chapter 4: Targeting Metastatic Disease: Challenges and New Opportunities PART II - Cachexia: a Debilitating Systemic Effect of Cancer Chapter 5: Signaling Pathways That Promote Muscle Catabolism in Cachexia Chapter 6: The Role of Interleukin-6 Cytokines in Cancer Cachexia Chapter 7: NF-kB Signaling in the Macroenvironment of Cancer Cachexia PART III - Therapy-induced Muscle Wasting Chapter 8: Therapy-Induced Toxicities Associated With the Onset of Cachexia Chapter 9: Bone-muscle Crosstalk in Advanced Cancer and Chemotherapy PART IV - Preventing and Targeting Cachexia in Cancer Chapter 10: New Developments in Targeting Cancer Cachexia Chapter 11: Exercise: A Critical Component of Cachexia Prevention and Therapy in Cancer

Swarnali Acharyya is a cancer biologist who performed her postdoctoral training at the Memorial Sloan Kettering Cancer Center and joined Columbia University as an Assistant Professor in 2014. Her laboratory investigates how metastatic tumors induce systemic changes in distant organs, such as skeletal muscle, and how these changes cause a debilitating syndrome in advanced cancer patients known as cachexia. This textbook aims to provide readers with an understanding of the systemic regulation and crosstalk between tumors and distant organs and its impact on the prognosis and treatment of advanced cancer patients.