Mechanisms of Disease Pathogenesis in Multiple Sclerosis

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Francisco Javier Quintana (Associate Scientist, Brigham and Women's Hospital; Professor of Neurology, Harvard Medical School; Brigham and Women's Hospital)

Mechanisms of Disease Pathogenesis in Multiple Sclerosis

Francisco Javier Quintana (Associate Scientist, Brigham and Women's Hospital; Professor of Neurology, Harvard Medical School; Brigham and Women's Hospital)

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English

Academic Press Inc
13 June 2024

Immunology; Neurology & clinical neurophysiology; Neurosciences

Mechanisms of Disease Pathogenesis in Multiple Sclerosis summarizes our current understanding on MS and its clinical features and monitoring with available biomarkers, focusing on mechanisms that drive disease pathogenesis and their control by genetic, environmental factors and novel therapies for disease management. The book is written for neurologists, neuroimmunologists and clinical, translational and basic researchers interested in mechanisms of neurodegeneration. Multiple Sclerosis (MS) is an autoimmune disease which targets the central nervous system (CNS). It is the most common cause of non-traumatic neurological disability in young adults with a prevalence of 1 in 1000 and increasing, hence the importance of this book.

Edited by: Francisco Javier Quintana (Associate Scientist Brigham and Women's Hospital; Professor of Neurology Harvard Medical School; Brigham and Women's Hospital)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm,
Weight: 450g
ISBN: 9780128238486
ISBN 10: 0128238488
Pages: 404
Publication Date: 13 June 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. Multiple Sclerosis, clinical course, open questions and unmet clinical needs 2. Novel Imaging Approaches in Multiple Sclerosis 3. Effect of infections on Multiple Sclerosis 4. T cells in Multiple Sclerosis. 5. B cells in Multiple Sclerosis. 6. Microglia in Multiple Sclerosis. 7. Monocytes in Multiple Sclerosis 8. Antigen Presenting Cells in Multiple Sclerosis. 9. Oligodendrocytes in Multiple Sclerosis. 10. Astrocytes in Multiple Sclerosis. 11. The Blood Brain Barrier in Multiple Sclerosis 12. Microbiome in Multiple Sclerosis.

Francisco J. Quintana, PhD, is an Associate Professor of Neurology at the Center for Neurologic Diseases, at Brigham and Women’s Hospital, Harvard Medical School, and an Associate Member at the Broad Institute of Harvard and MIT. Dr. Quintana’s research investigates signaling pathways that control the immune response and neurodegeneration, with the ultimate goal of identifying novel therapeutic targets and biomarkers for immune-mediated disorders. Dr. Quintana has published over 140 peer reviewed articles and book chapters. He is the recipient of the Lady Anne Chain Prize for Academic Excellence and Scientific Achievements, the Junior Investigator Award from the National Multiple Sclerosis Society, the Pathway to Independence Award of the National Institute of Allergy and Infectious Diseases, the Award for Outstanding Research Achievement form Nature Biotechnology and the Tecan Award for Innovation, the Harry Weaver Award from the National Multiple Sclerosis Society, the Young Mentor Award from Harvard Medical School and the Milestones in MS research from the National MS Society.

Reviews for Mechanisms of Disease Pathogenesis in Multiple Sclerosis

""…compiles the latest findings in multiple sclerosis (MS) research, organized into chapters that systematically cover the pathogenesis of MS.... By grounding the discussion in the most recent findings from experimental and clinical studies, the book explores processes such as T-cell and B-cell activation, neuroinflammation, and blood-brain barrier disruption. This book offers a comprehensive exploration of the molecular and cellular pathophysiology of MS, focusing on the mechanisms driving the progression and symptomatology of the disease. A standout feature of this book is its focus on linking cellular mechanisms with clinical applications. This connection gives a clear perspective on how pathophysiological processes translate into the physical and cognitive symptoms experienced by patients living with MS.... [A]n essential resource for understanding the intricate mechanisms driving MS pathology."" --©Doody’s Review Service, 2024, Sarah M Stuccio, MD (Thomas Jefferson University)