Isotopically Labeled Compounds: Recent Advances and Emerging Topics in Synthesis and Applications

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David Hesk (Director, Chemistry, Center for Drug Discovery, USA) Volker Derdau (Volker Derdau, Head of the Centre of Excellence for Isotope Chemistry and Senior Distinguished Scientist, Sanofi, Germany)

Isotopically Labeled Compounds

Name: Isotopically Labeled Compounds
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ISBN: 9780443191541

Recent Advances and Emerging Topics in Synthesis and Applications

David Hesk (Director, Chemistry, Center for Drug Discovery, USA), Volker Derdau (Volker Derdau, Head of the Centre of Excellence for Isotope Chemistry and Senior Distinguished Scientist, Sanofi, Germany)

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English

Elsevier - Health Sciences Division
29 April 2026

Analytical chemistry

Synthesis and Applications of Isotopically-Labelled Compounds: Recent Advances and Emerging Topics

Edited by: David Hesk (Director Chemistry Center for Drug Discovery USA), Volker Derdau (Volker Derdau, Head of the Centre of Excellence for Isotope Chemistry and Senior Distinguished Scientist, Sanofi, Germany)
Imprint: Elsevier - Health Sciences Division
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm,
Weight: 450g
ISBN: 9780443191541
ISBN 10: 0443191549
Pages: 414
Publication Date: 29 April 2026
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. General Introduction 2. Recent advances in tritium chemistry 3. Recent advances in carbon-14 chemistry 4. Recent advances in the chemistry of PET and SPECT isotopes 5. Recent advances in the chemistry of stable isotopes 6. Preclinical and clinical studies of pharmaceuticals supported by labelled compounds 7. Non pharmaceutical applications of labelled compounds 8. Emerging new fields in the chemistry of isotopes and their application 9. Deuterated APIs 10. Recent advances in the analysis of isotopically labelled compounds 11. Radiolabeling of large molecules 12. Summary and outlook

David Hesk is Director of Radiochemistry in the Center for Drug Discovery at RTI International. After obtaining his Ph.D. studying hydrogen isotope exchange chemistry under the direction of Professor J.R. Jones, Dr. Hesk worked for 27 years in the Radiochemistry and Labeled Compound Synthesis groups at Schering-Plough and Merck where he was responsible for the synthesis, purification, and analysis of isotopically labelled compounds in support of pharmaceutical research. There he maintained his interest in hydrogen isotope exchange labelling (HIE) and published the first example of the application of Crabtree’s catalyst in HIE in 1995. Volker Derdau is the Head of the Centre of Excellence for Isotope Chemistry and Senior Distinguished Scientist at Sanofi, based in Germany. With over 25 years of experience in the pharmaceutical industry, he is an expert in the area of homogeneous catalysis, including radiochemistry and photocatalysis. He is author of over 70 articles and patents.