Structural Biology of DNA Damage and Repair

Name: Structural Biology of DNA Damage and Repair
Price: 432 AUD
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ISBN: 9780841225749

Michael Stone

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Hardback

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English

Oxford University Press Inc
28 April 2011

DNA & Genome; Biochemistry; Toxicology (non-medical)

Series: ACS Symposium Series

The human genome is continuously exposed to many classes of genotoxins. Of these, three that will be discussed herein include 5,6-dihydroxy-5,6- dihydrothymine (thymine glycol; Tg), O6-methylguanine (O6MeG), and benzo[a]pyrene. In all cases, if the genome is not repaired, these and other genotoxic lesions precipitate serious biological consequences, including altered gene expression, mutation, and cell death. In addition to the genotoxic responses, it is increasingly being recognized that DNA lesions can alter the epigenetic profiles that are imprinted by naturally occurring DNA modifications.

The impetus for this volume came from a recent symposium sponsored by the ACS Division of Chemical Toxicology, bringing together scientists interested in the synthesis and structures of site-specific DNA adducts and in mechanistic aspects of DNA repair. This volume presents work at the interface between the structural biology of DNA damage and DNA repair.

Edited by: Michael Stone
Imprint: Oxford University Press Inc
Country of Publication: United States
Volume: 1041
Dimensions: Height: 232mm, Width: 158mm, Spine: 13mm
Weight: 352g
ISBN: 9780841225749
ISBN 10: 0841225745
Series: ACS Symposium Series
Pages: 138
Publication Date: 28 April 2011
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Michael P. Stone is Professor & Department Chairman of the Department of Chemistry at Vanderbuilt University.