Regulated Cell Death in Neurodegenerative Disorders

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Heba Mohamed Mansour, PhD (Central Administration of Biological, Innovative Products, and Clinical Studies (Bio-INN), Egyptian Drug Authority (EDA), Egypt) Aiman Saad El-Khatib, PhD (Egyptian Drug Authority (EDA) and Professor of Pharmacology and Toxicology in the Faculty of Pharmacy, Cairo University, Egypt)

Regulated Cell Death in Neurodegenerative Disorders

Heba Mohamed Mansour, PhD (Central Administration of Biological, Innovative Products, and Clinical Studies (Bio-INN), Egyptian Drug Authority (EDA), Egypt), Aiman Saad El-Khatib, PhD (Egyptian Drug Authority (EDA) and Professor of Pharmacology and Toxicology in the Faculty of Pharmacy, Cairo University, Egypt)

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English

Academic Press Inc
25 July 2025

Neurology & clinical neurophysiology; Neurosciences

Regulated Cell Death in Neurodegenerative Disorders is a comprehensive exploration of the mechanisms and implications of RCD within the realm of neurodegenerative diseases. The book delves into various forms of RCD such as apoptosis, necroptosis, ferroptosis, pyroptosis, and autophagy-mediated cell death, shedding light on their specific roles in disorders like Alzheimer’s, Parkinson’s, Multiple sclerosis, Amyotrophic lateral sclerosis, and Huntington’s. Written by leading experts, each chapter offers unique insights into cellular demise, providing valuable information on treatment options and therapeutic targets. The book features 14 chapters that cover molecular, cellular, and pharmacological mechanisms from an applied science perspective.

Topics include the importance of chaperones, kinases, growth factors, inflammaging, mitochondrial dynamics, and oxidative stress. It presents targeted strategies to prevent cell death, reflecting ongoing pursuits in understanding and innovating treatments for neurodegenerative diseases. By offering therapeutic strategies to modulate RCD, this book not only shares knowledge but also provides hope for future advancements in combating these debilitating conditions.

Edited by: Heba Mohamed Mansour PhD (Central Administration of Biological Innovative Products and Clinical Studies (Bio-INN) Egyptian Drug Authority (EDA) Egypt), Aiman Saad El-Khatib, PhD (Egyptian Drug Authority (EDA) and Professor of Pharmacology and Toxicology in the Faculty of Pharmacy, Cairo University, Egypt)
Imprint: Academic Press Inc
Country of Publication: United States [Currently unable to ship to USA: see Shipping Info]
Dimensions: Height: 235mm, Width: 191mm,
Weight: 450g
ISBN: 9780443328527
ISBN 10: 0443328528
Pages: 446
Publication Date: 25 July 2025
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. Regulated Cell Death (RCD): Discovery, Features, and Implications for Neurodegenerative Diseases 2. Crosstalk Between Different Regulated Cell Death Mechanisms in Neurodegenerative Diseases 3. Apoptosis in Neurodegenerative Disorders 4. Necroptosis in Neurodegenerative Disorders 5. Ferroptosis in Neurodegenerative Disorders 6. Pyroptosis in Neurodegenerative Disorders 7. Autophagy-Mediated Cell Death: Mechanisms and Implications in Neurodegenerative Disorders 8. Parthanatos in Neurodegenerative Diseases 9. Potential Targets for Regulating Cell Death in Neurodegenerative Disorders 10. Chaperones Control of Regulated Cell Death 11. Kinases Control of Regulated Cell Death in Neurodegenerative Disorders 12. Regulated Cell Death and Inflammaging in Neurodegenerative Disorders 13. Role of Oxidative Stress and Mitochondrial Dysfunction in Regulating RCD in Neurodegenerative Disorders 14. Therapeutic Approaches Targeting Regulated Cell Death in Neurodegenerative Diseases

Heba Mohamed Mansour, Ph.D. is currently the Manager of the Innovative Products' Technical Evaluation Unit at the Central Administration of Biological, Innovative Products, and Clinical Studies (Bio-Inn) at the Egyptian Drug Authority (EDA). She is a topic leader in the ICH working group (EWG S13), specializing in non-clinical safety assessments of oligonucleotide-based therapeutics (ONTs). Heba received a PhD degree in pharmacology and toxicology from the Faculty of Pharmacy, Cairo University in 2024. Her expertise encompasses a profound understanding of diverse cell death modalities in neurodegeneration and the exploration of potential drug repositioning strategies involving anti-cancer kinase inhibitors for neurodegenerative disorders. Her contributions extend to numerous research articles, prestigious international journal publications, book chapters, books, and comprehensive review articles, solidifying her interest in the field. Aiman Saad El-Khatib, Ph.D. is currently the Vice President of the Egyptian Drug Authority. He is a Professor of Pharmacology and Toxicology in the Faculty of Pharmacy, Cairo University since May 2002. He held several leadership positions in Cairo University including Vice President for Graduate Studies and Research Affairs, Dean of Faculty of Pharmacy, Vice Dean for Education and Students Affairs as well as Vice Dean for Community Service and Environment Development. Additionally, he held the post of Assistant Minister of Health and Population for Pharmaceutical Affairs. His primary research area of interest is the investigation of the pharmacological properties of various drugs, including natural products on the gastrointestinal tract, cardiovascular and central nervous systems. He published numerous articles in international journals. His awards include Cairo University Scientific Research Fosterage in the field of Theoretical and Applied Biological Sciences in 2004 and, Silver and Gold Medal of Merit from Egyptian Syndicate of Pharmacists in 2004 and 2005.

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Regulated Cell Death in Neurodegenerative Disorders

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