Rational Basis for Clinical Translation in Stroke Therapy

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"Giuseppe Micieli (Department of Emergency Neurology, IRCCS ""C. Mondino"" National Neurological Institute, Pavia, Italy)" Diana Amantea (Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy)

Rational Basis for Clinical Translation in Stroke Therapy

"Giuseppe Micieli (Department of Emergency Neurology, IRCCS ""C. Mondino"" National Neurological Institute, Pavia, Italy)", Diana Amantea (Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy)

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English

CRC Press Inc
27 August 2014

Neurology & clinical neurophysiology; Pharmacology; Neurosciences; Pharmaceutical technology

Series: Frontiers in Neurotherapeutics Series

Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy.

Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translate novel strategies into the clinical setting. Rational Basis for Clinical Translation in Stroke Therapy presents the most recent promising preclinical approaches and the most updated clinical evidence for treating stroke patients. By bringing together the experience of accomplished stroke researchers and clinicians, the book is a useful tool for improving the treatment and management of stroke patients.

The book describes current approaches for the management of stroke patients including thrombolysis and mechanical recanalization procedures as well as other clinically relevant topics such as diagnosis, imaging, risk factors, and prevention. Also described are emerging interventions based on the use of stem cells, botulinum toxin, and antidepressants which complement emergency stroke treatment and conventional rehabilitation procedures.

Clinical approaches are integrated with the most promising therapeutic opportunities based on targeting the immune system, hypothermia, and postconditioning. The book also covers issues related to the improvement of R&D strategies in stroke therapeutics, aimed at the implementation of preclinical approaches with stroke model guidelines and at the optimization of clinical trial design. This volume is a reference for all those interested in the rational development of novel stroke therapeutics.

Edited by: "Giuseppe Micieli (Department of Emergency Neurology IRCCS ""C. Mondino"" National Neurological Institute Pavia Italy)", Diana Amantea (Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy)
Imprint: CRC Press Inc
Country of Publication: United States
Volume: 1
Dimensions: Height: 234mm, Width: 156mm, Spine: 33mm
Weight: 861g
ISBN: 9781466594975
ISBN 10: 1466594977
Series: Frontiers in Neurotherapeutics Series
Pages: 538
Publication Date: 27 August 2014
Audience: College/higher education , General/trade , Professional and scholarly , Primary , ELT Advanced
Format: Hardback
Publisher's Status: Active

Update on the Clinical Management of Stroke Patients. Clinical Needs: Diagnosis and Brain Imaging. Lessons from the Clinical Setting to Improve Translational Approaches. Promising Therapeutic Strategies for Acute Stroke Treatment. Novel Approaches to Promote Recovery.

"Giuseppe Micieli is director of the Department of Emergency Neurology at the IRCCS ""C. Mondino"" Foundation in Pavia, Italy, as well as adjunct professor at the University of Pavia. He received his degree in medicine and surgery from the University of Pavia and holds specialization degrees in neurology and clinical pharmacology. He is former director of the Laboratory of Vegetative Physiopathology, the Headache Centre, and the Sub-intensive Unit of Cerebrovascular Diseases at the IRCCS ""C. Mondino"" Foundation. He is also the former leader of the Emergency Neurology and Stroke Unit of the Humanitas Clinical Institute in Rozzano, Milan. Dr. Micieli has published more than 170 peer-reviewed articles and held numerous leadership positions including coordinating roles for the Stroke Unit Network and the Italian Stroke Forum. Diana Amantea is aggregate professor of pharmacology in the Department of Pharmacy, Health Sciences and Nutrition at the University of Calabria, Italy. She also leads the Stroke Research Unit at the Center of Preclinical and Translational Pharmacology located in the University of Calabria. Dr. Amantea received her PharmD from the University of Calabria and her PhD in pharmacology from the University of Birmingham. Her research focuses on understanding the inflammatory mechanisms occurring during ischemic brain injury in order to identify novel pharmacological targets for stroke therapy."