Phosphoinositides I

Enzymes of Synthesis and Degradation

Tamas Balla, Matthias Wymann, John D. York

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English

Springer
16 April 2014

Lipids; Enzymology; Cellular biology (cytology)

Series: Subcellular Biochemistry

Summary
Details

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Edited by: Tamas Balla, Matthias Wymann, John D. York
Imprint: Springer
Edition: 2012 ed.
Volume: 58
Dimensions: Height: 235mm, Width: 155mm, Spine: 20mm
Weight: 569g
ISBN: 9789401781572
ISBN 10: 9401781575
Series: Subcellular Biochemistry
Pages: 356
Publication Date: 16 April 2014
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active