Oligosaccharides

CHAPTER 1: INTRODUCTION; Location of oligosaccharides; Therapeutic potential; Nomenclature; Structural representation; Problems associated with oligosaccharide assembly; Further reading; CHAPTER 2: BIOLOGICAL ROLES OF OLIGOSACCHARIDES; Biosynthesis of some biologically important oligosaccharides; Carbohydrates as carriers of biological information; Lectins: Carbohydrate binding proteins; Diseases in which oligosaccharides play an important role; Further reading; CHAPTER 3: SYNTHESIS OF CARBOHYDRATE ACCEPTORS; General introduction to protecting group strategies; Specific protecting group strategies; Selection protection reactions; Synthesis of branched chain oligosaccharides; Further reading; CHAPTER 4: SYNTHESIS OF CARBOHYDRATE DONORS; Glycosyl acetates and thioglycosides; Glycosyl halides; Glycosyl selenides; Trichloroacetimidates; n-Pentyl glycosides; Vinyl glycosides; Glycals; Further reading; CHAPTER 5: ASSEMBLY OF OLIGOSACCHARIDES; Methods to control the configuration of newly formed anomeric bonds; Synthesis of beta-linked mannopyranosides; One pot synthesis of oligosaccharides; Further reading; CHAPTER 6: LITERATURE EXAMPLES OF OLIGOSACCHARIDES; An efficient synthesis of a high mannose type nonasaccharide; Stereoselective construction of the tetrasaccharyl cap portion of Leishmania lipophosphoglycan; A highly convergent synthesis of the tetragalactose moiety of the glycosyl phosphatidyl inositol anchor of the variant surface glycoprotein of Trypanosoma brucei; Synthesis of sialyl-Lewis; Further reading; CHAPTER 7: ALTERNATIVE STRATEGIES FOR SYNTHESISING OLIGOSACCHARIDES; Enzymatic synthesis of oligosaccharides; Polymer supported synthesis of oligosaccharides; Specific examples of polymer supported synthesis; Polymer supported synthesis employing enzymes; Further reading