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New Trends In Chemotherapy: Facile Synthesis, In silico Studies, and Biological Assessment of Novel Pyrazolo[3,4-b]pyridine by Ibrahim F Nassar at Abbey's Bookshop,
New Trends In Chemotherapy: Facile Synthesis, In silico Studies, and Biological Assessment of Novel Pyrazolo[3,4-b]pyridine...
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Ibrahim F Nassar

New Trends In Chemotherapy

Facile Synthesis, In silico Studies, and Biological Assessment of Novel Pyrazolo[3,4-b]pyridine...

Ibrahim F Nassar

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English
Eliva Press
14 July 2024
Chemistry
The contemporary work depicts synthesizing an innovative sequence of polyfunctionalized Pyrazolo[3,4-b]pyridine congeners ES1-ES18 and assessed for antimicrobial, antitumor, telomerase inhibition, and Anti-hepatitis B efficacies applying an array of techniques. Fortunately, most of the compounds demonstrated auspicious bio efficiencies. Additionally, in silico simulation was executed for determining the synthetic Pyrazolo[3,4-b]pyridines anticipated mode of action. Compounds ES4, ES5, and ES6 were picked as the most potent and efficient candidates versus the telomerase enzyme [PDB id: 2B2A]. The consequences exposed that compound ES5 is the extremely credible operative in contradiction of telomerase enzyme as it disclosed the best binding score and interaction pose. These initial outcomes may improve in introducing more research strategies converged on pyrazolo[3,4-b]pyridines, exclusively those with anticipated bioefficacy, ultimate ADMET parameters, and constructive prospects.
By:  
Imprint:   Eliva Press
Dimensions:   Height: 229mm,  Width: 152mm,  Spine: 3mm
Weight:   91g
ISBN:   9789999320283
ISBN 10:   9999320287
Pages:   58
Publication Date:  
Audience:   General/trade ,  ELT Advanced
Format:   Paperback
Publisher's Status:   Active

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