Mosquito Gene Drives and the Malaria Eradication Agenda

Rebeca Carballar-Lejarazú

$292

Hardback

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English

Jenny Stanford Publishing
24 February 2023

Epidemiology & medical statistics; Medical genetics; Genetics (non-medical)

Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

Edited by: Rebeca Carballar-Lejarazú
Imprint: Jenny Stanford Publishing
Country of Publication: Singapore
Dimensions: Height: 229mm, Width: 152mm,
Weight: 700g
ISBN: 9789814968331
ISBN 10: 9814968331
Pages: 360
Publication Date: 24 February 2023
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Dr. Rebeca Carballar-Lejarazú’s research is focused on insect molecular genetics, vector biology, and the development of synthetic approaches to prevent transmission of mosquito-borne diseases. She has used several genetic strategies such as transposon-based random integration, phiC31 docking-site integration and CRISPR/Cas9 site-specific genome editing technologies to develop transgenic mosquitoes. Dr. Carballar-Lejarazú is currently working on the development, optimization, and evaluation of a CRISPR/Cas9 gene drive system to engineer mosquitoes that resist malaria parasites (population modification/replacement) in two main malaria African vectors Anopheles gambiae and Anopheles coluzzii. Her insect interests have been centered mainly on vector mosquitoes. However, in 2014, she started a collaboration with Professor Sonqing Wu to study biopesticides to control crop pests in China.