Molecular Mechanisms of Cardiac Hypertrophy and Failure

Richard A. Walsh

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English

CRC Press
29 November 2005

Anatomy; Medical genetics; Cardiovascular medicine; Molecular biology

Unique in its focus on this particular field of cardiovascular science, ""Molecular Mechanisms of Cardiac Hypertrophy and Failure"" reviews current knowledge of the mechanisms contributing to heart failure.

Bringing together an internationally renowned team of contributors, the text provides expert reviews on the latest advances in molecular and cell biology, biochemistry and pharmacology. Richly illustrated and suitable for a wide audience of clinicians and basic scientists in academia and industry, the book has particular emphasis on the following key areas: - cardiac hypertrophy - contractile depression - arrhythmogenesis - genetics - the clinical implications of the research in these areas. With a broad, multi-disciplinary appeal, this important text will be of interest to clinical cardiologists, vascular medicine specialists, hematologists, and internists, as well as members of the cardiovascular research community and pharmaceutical and biotechnology industries.

By: Richard A. Walsh
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm, Spine: 49mm
Weight: 1.542kg
ISBN: 9781842142486
ISBN 10: 1842142488
Pages: 780
Publication Date: 29 November 2005
Audience: Professional and scholarly , Professional and scholarly , Professional & Vocational , Undergraduate , Further / Higher Education
Format: Hardback
Publisher's Status: Active

MECHANISMS FOR CARDIAC HYPERTROPHY. Mechanisms for Normal CV Growth and Development. Cell Cycle Control. Apoptosis. G-Protein Coupled Receptors. Mechanotransduction. Extracellular Matrix. Physiologic vs. Pathologic Hypertrophy. Abnormal Signal Transduction. Tissue Regeneration. MECHANISMS FOR CONTRACTILE DEPRESSION. Normal Excitation Contraction Coupling and Calcium Homeostasis. Calcium Homeostasis. Myocardial Ischemia and Infarction. Cardiac Remodeling. Inflammation. Phosphorylation/Dephosphorylation. Cytoskeleton. Environmental Factors in Cardiac Hypertrophy and Failure. ELECTRICAL PROPERTIES. Normal Action Potential Generation Propagation and Repolarization. Depolarization Abnormalities. Repolarization Abnormalities. Cell-Cell Transmission Abnormalities. GENETIC BASIS FOR CARDIOMYOPATHY. Genomic Analysis. Monogenetic Abnormalities. Polygenic Abnormalities and the Roles of Transcriptional Profiling and Proteomics.

Walsh, Richard A.