Molecular Mechanisms of Cardiac Hypertrophy and Failure

Richard A. Walsh

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English

CRC Press
16 September 2019

Anatomy; Medical genetics; Cardiovascular medicine; Molecular biology

This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.

By: Richard A. Walsh
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 254mm, Width: 178mm,
Weight: 453g
ISBN: 9780367391621
ISBN 10: 0367391627
Pages: 784
Publication Date: 16 September 2019
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

MECHANISMS FOR CARDIAC HYPERTROPHY. Mechanisms for Normal CV Growth and Development. Cell Cycle Control. Apoptosis. G-Protein Coupled Receptors. Mechanotransduction. Extracellular Matrix. Physiologic vs. Pathologic Hypertrophy. Abnormal Signal Transduction. Tissue Regeneration. MECHANISMS FOR CONTRACTILE DEPRESSION. Normal Excitation Contraction Coupling and Calcium Homeostasis. Calcium Homeostasis. Myocardial Ischemia and Infarction. Cardiac Remodeling. Inflammation. Phosphorylation/Dephosphorylation. Cytoskeleton. Environmental Factors in Cardiac Hypertrophy and Failure. ELECTRICAL PROPERTIES. Normal Action Potential Generation Propagation and Repolarization. Depolarization Abnormalities. Repolarization Abnormalities. Cell-Cell Transmission Abnormalities. GENETIC BASIS FOR CARDIOMYOPATHY. Genomic Analysis. Monogenetic Abnormalities. Polygenic Abnormalities and the Roles of Transcriptional Profiling and Proteomics.

Walsh, Richard A.