Mathematical Modeling in Systems Biology

An Introduction

Brian P. Ingalls (University of Waterloo)

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English

MIT Press
07 June 2022

Applied mathematics; Molecular biology

An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology.

An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology.

Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses- they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3-8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.

By: Brian P. Ingalls (University of Waterloo)
Imprint: MIT Press
Country of Publication: United States
Dimensions: Height: 229mm, Width: 178mm,
Weight: 369g
ISBN: 9780262545822
ISBN 10: 0262545829
Pages: 424
Publication Date: 07 June 2022
Recommended Age: From 18 years
Audience: General/trade , ELT Advanced
Format: Paperback
Publisher's Status: Active

Brian P. Ingalls is Associate Professor in the Departments of Applied Mathematics, Biology, and Chemical Engineering at the University of Waterloo, Canada. He is the coeditor of Control Theory and Systems Biology (MIT Press, 2010).