There is always potential for hazards during chemical reactions that can lead to accidents resulting in loss of time, equipment, products and harm to people.
The hazards may result from uncontrolled exothermic reactions or secondary exothermic reactions such as decomposition of a reactant, reagent or product. Hazards may also occur from impurities or metal residues that can catalyze undesired exothermic reactions or decompositions. Many organic reactants, reagents, products as well as solvents have varying degrees of toxic effects and/or fire hazard if not handled properly. Improperly treated waste may also be a source of many hazards. Managing all these hazards effectively is very important for carrying out reactions safely, particularly on large scale. To achieve this goal, chemists and engineers need a clear understanding of the thermal characteristics of chemical reactions derived from accurate quantitative measurements and clear scientific knowledge of reaction mechanisms. They also need to build an expertise on handling toxic and flammable materials and proper procedures to waste treatment and disposal. To address these objectives, this book covers many topics on management of potential hazards in the chemical and pharmaceutical industries. The topics range from classical batch reactions to the latest innovative applications of continuous processes and flow chemistry. The applications range in scale from bench to manufacturing. The book contains 16 chapters on different aspects of managing chemical reaction hazards contributed by a group of internationally renowned leading chemical safety and hazard management experts.
Their contributions make this book a valuable addition to the scientific literature.
Edited by:
Jaan A. Pesti,
Ahmed F. Abdel-Magid
Imprint: Oxford University Press Inc
Country of Publication: United States
Dimensions:
Height: 230mm,
Width: 161mm,
Spine: 30mm
Weight: 792g
ISBN: 9780841230330
ISBN 10: 0841230331
Series: ACS Symposium Series
Pages: 488
Publication Date: 10 September 2015
Audience:
Professional and scholarly
,
Undergraduate
Format: Hardback
Publisher's Status: Active
1. Managing Hazards for Scale Up of Chemical Manufacturing Processes 2. Safety by Design, The Bedrock for Managing Process Hazards 3. Strategies for Safely Handling Industrial Azide Reactions: The Three Traps 4. Chemical Reaction Safety in the Research Laboratory ? Where It All Begins 5. Systems and Protocols for Evaluating Hazardous Reaction Issues During Early Stage Chemistry 6. Process Safety in the Large-Scale Manufacture of an Adamantane ?-Ketoacid Precursor of Saxagliptin 7. Thermal Risk Assessment: A Powerful Tool for Route Selection for Scale-Up Applied to DielsDSAlder Reactions 8. Rapid Scale Up Using Hazardous Reagents: The Challenge of Risk Mitigation 9. Development of a Multi-Kilogram Procedure To Prepare, Use, and Quench Ethyl Diazoacetate 10. Synthesis and Processing of Energetic Materials DS Considerations for Safe Scale-up of Potentially Hazardous Reactions 11. Addressing Process Safety Hazards: Replacement of para-Methoxybenzyl Chloride Leads to a Safer and Shorter Route 12. Managing Hazardous Reactions and Compounds in Process Chemistry 13. A New Paradigm in Oxidative Cleavage Reaction: The Use of Continuous Reactors To Enable Safe Scale Up of Ozonolysis 14. Development of Flow Processes for the Syntheses of N-Aryl Pyrazoles and Diethyl Cyclopropane-cis-1,2-dicarboxylate 15. Technology for Continuous Production of Fine Chemicals 16. Continuous Flow Chemistry of Metal Mediated Carboxylation and ?-Arylation Reactions
