Liposomes in Drug Delivery: What, Where, How and When to deliver

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Sophia G. Antimisiaris (Professor, Department of Pharmace Technology and Analysis, University of Patras, Patra, Greece)

Liposomes in Drug Delivery

What, Where, How and When to deliver

Sophia G. Antimisiaris (Professor, Department of Pharmace Technology and Analysis, University of Patras, Patra, Greece)

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English

Academic Press Inc
15 April 2024

Pharmaceutical industries; Pharmacology

Liposomes in Drug Delivery: What, Where, How and When to Deliver is a concise, well-structured reference covering all the important issues related to the potential of this technology. Organized to provide practical information to researchers from any discipline with a particular therapeutic or bio-active substance to deliver, this book helps readers understand if liposomes can be of benefit for their particular need, what is the best type of liposome to use according to what needs to be delivered, where/when to deliver it, and how to design/prepare/characterize/investigate/optimize liposome properties for a particular application.

The book is structured in Four parts. The first covers in a concise but in-depth way, what liposomes are, which are the liposome types, advantages/disadvantages, and what is their stability, characterization methods, in vitro stability, and in vivo fate after different administration methods (routes). The second part focuses on the different mechanisms for liposomal drug delivery. Methodologies/technologies for manipulation of liposome structure/properties in order to design liposomes for particular delivery applications. Specific roadmaps for liposome design are discussed, including components to incorporate in liposomes for specific types of encapsulated molecules or specific routes of administration. The third part covers liposome applications for drug delivery. It focuses on specific delivery considerations for particular diseases. Finally, the fourth part covers methods of liposome fabrication.

Edited by: Sophia G. Antimisiaris (Professor Department of Pharmace Technology and Analysis University of Patras Patra Greece)
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 191mm,
ISBN: 9780443154911
ISBN 10: 0443154910
Pages: 440
Publication Date: 15 April 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Part I – Basic concepts of Liposome-Assisted Drug Delivery 1. Introduction to Liposome Assisted Drug Delivery 2. Basic concepts of Liposome: components, structures, properties and classification 3. Liposome Characterization Methodologies(Physical and Chemical Methods) 4. Liposome Characterization Methodologies - Morphological Assessments by Microscopy 5. Liposome Stability and Integrity 6. In vivo fate of Liposomes: Biodistribution and cell membrane interactions Part II – Mechanisms of Liposome Drug Delivery 7. Liposomes in controlled drug delivery: Controlling drug release kinetics and biodistribution/pharmacokinetics 8. Liposome surface modifications-Engineering techniques 9. Activatable liposomes: Ultrasound-activated liposomes and lipid vesicles Part III – Liposome Applications in drug delivery 10. Liposomes for drug delivery to the brain 11. Liposomes for drug delivery to cancer cells 12. Liposomes as vaccine delivery systems 13. Liposomes as DNA, mRNA and oligonucleotide delivery vectors 14. Liposomes for drug delivery by localized routes of administration 15. Liposome for drug delivery against infectious diseases 16. Liposomes for drug delivery via biomaterials 17. Liposomes for delivery of substances for other (non-therapeutic) applications Part IV –Liposome fabrication 18. Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs ) 19. Size reduction, purification, sterilization and storage/packaging of Liposomes 20. Methods for preparation of Giant liposomes: Conventional methods; Modified electro-techniques 21. Microfluidic methods for liposome formation 22. Supercritical fluids and other novel methods for liposome formation 23. Design of experiment approaches for liposome property optimization 24. Development of generic liposome products for drug delivery Part V – Conclusions and Perspectives 25. Success stories, Final remarks and directions of the field

Dr. Antimisiaris’ lab has extensive experience (more than 25 years) in design and production of liposomal and lipid/polymer/cyclodextrin hybrid nanoparticulates for drug and/or imaging agent delivery and targeting to specific target cells. Several administration routes have been investigated or are under investigation in regards to the specific requirements of NPs for each specific route (such as: iv, ip, oral, lung, ocular (intravitreal), vaginal, oral). Her laboratory also has long term collaborations with industries and is involved in setting up large-scale manufacturing techniques. She has experience as WP-leaders (partners) in several large scale European Collaborative Projects, as Shiva (FP6 –for preparation of vaginal microbicides), and lately NAD (Nanoparticles for diagnosis and Therapy of AD) (WP-leader for Design and preparation of NPs with affinity for Abeta peptides). Her team have also been working for many years on the application of arsonolipid-containing liposomes for therapy of cancer with promising results in vitro as well as in vivo results. They also investigate the development of novel platforms for sustained release of drugs following ocular (intravitreous), vaginal or subcutaneous administration.