Immunomodulators Part B brings together a curated set of research-focused chapters that explore how the immune system is influenced by microbes, immune checkpoint molecules, genetic regulation, and emerging therapeutic strategies. It covers the role of the microbiome and microbial products in shaping immune responses relevant to gastrointestinal cancers, examines VISTA as a “double-edged” checkpoint in cancer and autoimmunity, and uses bioinformatics to uncover immune-modulatory patterns in HPV-associated head and neck squamous cell carcinoma and bladder cancer.
1. Microbiome and microbial products as immunomodulators: Implications for gastrointestinal cancers Shriyans Reddy Yendreddy, Divya Patchigolla, Satyendra Singh, Kirti Baghel, Rupal Ojha, and Vijay Kumar Prajapati 2. VISTA as a Double-Edged immune checkpoint molecule in cancer and autoimmunity Ali Mert Sencer and Sibel Kalyoncu 3. Investigating the immune modulatory association of miRNAs in HPV-associated HNSCC individuals: A bioinformatics approach Ankur Datta, M. Muthu Meenakshi, Susanna Daniels, B. Varsha, and C. George Priya Doss 4. Transcriptomic Insights into Epigenetic and Immunomodulatory Roles of Nuclear Histone Genes in Bladder Cancer: A Bioinformatics Approach Santhosh Mudipalli Elavarasu, Insha Asheem, Nihla M, Udhaya Kumar. S, R. Magesh, Sasikumar K, and George Priya Doss C 5. Identification of Common Hub Genes and Pathways in Systemic Lupus Erythematosus and Cervical Cancer Using Bioinformatics Approach Tamizhini Loganathan, Madhulekha, Hatem Zayed, and George Priya Doss C 6. Transcriptomic Profiling Reveals Immune Pathway Dysregulation and Key Interferon-Responsive Genes in Systemic Lupus Erythematosus Prasanna Kumar Selvam, Supraja Mohan and Karthick Vasudevan 7. Peptides and Peptidomimetics as Immunomodulator Agents Targeting Neglected Tropical Diseases Sheila Oliveira de Souza, Leandro Rocha Silva, Manuele Figueiredo da Silva, Maria Gabriele Cordeiro Domingos, Eziane Dantas da Silva, João Xavier de Araújo-Júnior, Paulo Fernando da Silva Santos-Júnior, Ana Catarina Rezende Leite, and Edeildo Ferreira da Silva Júnior 8. Aptamers as immunomodulatory therapeutic alternatives targeting Neglected Tropical Diseases (NTDs) Leandro Rocha Silva, Wadja Feitosa dos Santos Silva, Ana Clara Ferreira de Melo, Érica Erlanny da Silva Rodrigues, and Edeildo Ferreira da Silva-Júnior
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.