Iminosugars: From Synthesis to Therapeutic Applications

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Philippe Compain (Institut de Chimie Organique et Analytique, Université d�Orléans, France) Olivier R. Martin (Institut de Chimie Organique et Analytique, Université d�Orléans, France)

Iminosugars

From Synthesis to Therapeutic Applications

Philippe Compain (Institut de Chimie Organique et Analytique, Université d�Orléans, France), Olivier R. Martin (Institut de Chimie Organique et Analytique, Université d�Orléans, France)

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English

John Wiley & Sons Inc
19 October 2007

Pharmacology; Carbohydrates; Pharmaceutical technology

Iminosugars form undoubtedly the most attractive of carbohydrate mimics reported so far. In these structures, the substitution of the endocyclic oxygen of sugars by a basic nitrogen atom leads to remarkable biological properties and raises many challenges in organic synthesis. Since the discovery of their biological activity as glycosidase inhibitors in the 1970’s, these polyvalent molecules have progressively made their way from the laboratory to the clinic.

The impressive series of discoveries in the field over the past ten years indicates clearly that it is “a boom time” for iminosugar chemistry and biology. The scope of their profile as inhibitors has been extended to a number of enzymes such as phosphorylases, glycosyltransferases or metalloproteinases, and iminosugars now constitute lead compounds for the development of new therapeutic agents for a wide range of diseases including diabetes, viral infections, lysosomal storage disorders and tumor metastasis.

Latest developments, from iminosugar synthesis to their use in clinical studies, are presented in this book, which contains contributions from over fifteen of the major chemists, biochemists and drug developers in this rapidly expanding field. An extensive table correlating the structures of more than 600 iminosugars of therapeutic interest with their biological activities is also included in the book and should prove particularly useful to aid with the design and the discovery of novel bioactive substances.

Iminosugars: From Synthesis to Therapeutic Application provides a unique resource for academic and industrial researchers working in the field of iminosugars and glycomimetics of biological and/or therapeutic interest: organic chemists, medicinal chemists, carbohydrate chemists and medical scientists.

Edited by: Philippe Compain (Institut de Chimie Organique et Analytique Université d�Orléans France), Olivier R. Martin (Institut de Chimie Organique et Analytique, Université d�Orléans, France)
Imprint: John Wiley & Sons Inc
Country of Publication: United States
Dimensions: Height: 252mm, Width: 175mm, Spine: 33mm
Weight: 989g
ISBN: 9780470033913
ISBN 10: 0470033916
Pages: 482
Publication Date: 19 October 2007
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Philippe Compain and Olivier R. Martin CNRS, University of Orléans, France

Reviews for Iminosugars: From Synthesis to Therapeutic Applications

This is book is a must buy for anyone interested in carbohydrate and/or medicinal chemistry. (Journal of the American Chemical Society, May 14, 2008) Given the recent resurgence of interest in this class of compounds, the text is a welcome review of the area. (Journal of Medicinal Chemistry, 2008)