The Neuroscience of Psychedelics

The Pharmacology of What Makes Us Human

Genís Ona, José Carlos Bouso

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English

Park Street Press,U.S.
28 November 2024

Neurology & clinical neurophysiology; Pharmacology; Neurosciences; Mind, Body, Spirit: thought & practice

A detailed look at the neural and biological mechanisms of psychedelic use

• Examines the main pharmacological properties of psychedelic substances, including LSD, DMT, psilocybin, ayahuasca, mescaline, ketamine, ibogaine, salvia, and MDMA

• Explains the physiological mechanisms behind visionary effects, including what is happening in the brain and how each psychedelic is processed by the body

• Shares safe strategies for using psychedelics, including harm-reduction techniques, and looks at where the future of psychedelic therapies is likely to go

With the widespread legalization of marijuana and the increasing use of psychoactives in controlled therapy settings, further research and understanding of psychedelics is now possible. Yet while individual accounts of their use abound, exactly what’s happening to the brain and body when using these substances is still not widely understood.

Longtime pharmacological researcher Genís Ona presents a comprehensive look at the main pharmacological properties of psychedelic substances, including LSD, DMT, psilocybin, ayahuasca, mescaline, ketamine, ibogaine, salvia, tropane alkaloids, and MDMA. Exploring how psychedelics work within the brain, Ona shares results from his extensive research to reveal the physiological mechanisms that allow these molecules to have their visionary effects, explaining what is happening at the receptor level as well as the “cascade” effects that differ from substance to substance. He examines how the body processes each substance, describing how each psychedelic is released, absorbed, distributed, metabolized, and eliminated. He also details possible dangerous interactions between these substances and other drugs as well as their potential toxicity.

Although his main focus is the biological and neurological effects of psychedelics, Ona also explores the mystical and spiritual dimension of psychedelic use, particularly as practiced in Indigenous traditions, showing how they enable access to a profound spiritual territory. He shares safe strategies for using psychedelics and looks at where the future of psychedelic therapies is likely to go, with an emphasis on ensuring that traditional knowledge is respected, honored, and protected.

By: Genís Ona
Foreword by: José Carlos Bouso
Imprint: Park Street Press,U.S.
Country of Publication: United States
Edition: 2nd Edition, Revised Edition of Your Brain on Psychedelics
Dimensions: Height: 229mm, Width: 152mm, Spine: 20mm
Weight: 429g
ISBN: 9798888500040
Pages: 264
Publication Date: 28 November 2024
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Foreword by José Carlos Bouso, Ph.D. Preface 1 Brief Introduction to Pharmacology Etymological Origins Main Pharmacological Concepts Nervous System • Neurons, Synapses, and Action Potentials • Pharmacokinetics and Pharmacodynamics • Neurotransmitters • Receptors • Modifying Receptor Function Why Psychedelic Pharmacology? Pharmacology and Complexity References for Further Study 2 Pharmacological Classification of the Main Psychedelic Drugs: Structures and Major Groups Simple Tryptamines, including Psilocybin and DMT Ergolamines, including LSD Phenethylamines, including Mescaline and MDMA NMDA Receptor Antagonists, including Ketamine New Tryptamines Atypical Psychedelics Tabernanthe iboga • Salvia divinorum • Datura stramonium References for Further Study 3 Biological Targets of Psychedelic Drugs Simple Tryptamine Targets Psilocybin • DMT and Ayahuasca Ergolamine Targets LSD • LSA Phenethylamine Targets Mescaline • MDMA Targets of NMDA Receptor Antagonists, including Ketamine Targets of New Tryptamines Targets of Atypical Psychedelics Ibogaine/Noribogaine • Salvinorin-A • Datura stramonium References for Further Study 4 Characteristic Aspects of Psychedelic Pharmacology PHARMACOKINETICS Initial Phases of the Processing of Psychedelics Release • Absorption • Distribution Metabolism Metabolism and Aging • Main Centers and Enzymes Responsible for Metabolism Relevant Aspects in the Metabolism of Psychedelic Drugs Psilocybin • DMT/Ayahuasca • LSD • MDMA • Mescaline • Ketamine • Ibogaine/Noribogaine • Salvinorin-A • Tropane Alkaloids Elimination PHARMACODYNAMICS Therapeutic Effects of Psychedelics Antidepressant, Anti-inflammatory, and Neuroprotective Effects • Therapeutic Effects of Atypical Psychedelics • Increased Neuroplasticity • Neurological Evidence of Psychedelics’ Therapeutic Effects • Hormonal Effects • Psychological Effects Microdosing Psychedelics as an Emerging Trend Adverse Effects in the Therapeutic Use of Psychedelics Toxicity • Studying the Safety of Psychedelics • Health Risks When Using Psychedelic Drugs Therapeutically Psychoactive Effects of Psychedelics Data on Psychedelics' Psychoactive Effects Tolerance References for Further Study 5 Harm Reduction in Your Use of Psychedelic Drugs Take Care of Yourself • Check What You Bought • Don’t Get Creative with Routes of Administration • Keep Hydrated • Don’t Mix • Be Patient 6 A Look into the Future: Promises and Challenges Marketing of Psychedelic Therapies The Role of Traditional Knowledge To Trip or Not to Trip Appendix I: The Legal Status of Psychedelic Drugs around the World Appendix II: Glossary Index

Genís Ona, Ph.D., is a psychologist specializing in pharmacology research. An associate professor at the Universitat Rovira i Virgili (URV), he is a member of the Spanish Society of Psychedelic Medicine and of the working group on psychedelics at the Catalan Society of Psychiatry and Mental Health. He has published more than 50 peer-reviewed scientific articles about psychedelic drugs. Currently working as a study coordinator in the psychedelic trials taking place at Sant Joan de Déu Hospital, Barcelona, and in the Medical Anthropology Research Center at URV, he lives in a house in the middle of the wooded Catalan mountains.