Hepatitis B Virus: Molecular Mechanisms In Disease And Novel Strategies For Therapy

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Wolfgang Helmut Caselmann (Medical Director, Bavarian Ministry Of The Environment, Germany) Rajen Koshy (Royal Postgraduate Medical Sch, Uk)

Hepatitis B Virus

Molecular Mechanisms In Disease And Novel Strategies For Therapy

Wolfgang Helmut Caselmann (Medical Director, Bavarian Ministry Of The Environment, Germany), Rajen Koshy (Royal Postgraduate Medical Sch, Uk)

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English

Imperial College Press
02 July 1998

Infectious & contagious diseases; Hepatology; Medical microbiology & virology; Molecular biology

"The hepatitis B virus covers both the molecular grounds of hepatitis B replication and gene expression ""in vivo"" and in model systems, and the clinical impact of genetic variants or immune response in chronic infection. This text emphasizes the molecular mechanisms underlying diseases associated with the virus, including liver carcinogenesis. It discusses their possible relevance to therapy and to the prevention of infection. It also discusses rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy."

Edited by: Wolfgang Helmut Caselmann (Medical Director Bavarian Ministry Of The Environment Germany), Rajen Koshy (Royal Postgraduate Medical Sch, Uk)
Imprint: Imperial College Press
Country of Publication: United Kingdom
Dimensions: Height: 230mm, Width: 156mm, Spine: 18mm
Weight: 612g
ISBN: 9781860940071
ISBN 10: 1860940072
Pages: 340
Publication Date: 02 July 1998
Audience: College/higher education , Professional and scholarly , Further / Higher Education , Undergraduate
Format: Hardback
Publisher's Status: Active

Part 1 Molecular biology of hepatitus B virus: replication of HBV, C. Seeger; HBV gene expression, A. Siddiqui; animal models and experimental systems for the study of hepadnaviruses, W.H. Gerlich. Part 2 Infection and chronic diseases: natural course of HBV infection, H. Blum; genetic variants of HBV and their implications in disease, T. Harrison; the immunology of chronic hepatitis B, B. Rehemann and F. Chisari. Part 3 Hepatocellular carcinoma: HBV DNA integrationa and insertional mutagenesis, K. Koike; HBV transactivation and signal transduction, W.H. Caselmann and R. Koshy; oncogenes, tumour suppressors, and co-factors in hepatocellular carcinoma, M.A. Buendia. Part 4 Rational approaches for the prevention of infection and therapy: novel vaccines, F. Schoedel; cytokines and therapy, H. Thomas; the development of targetable vectors for the liver and prospects for gene therapy, L. Weiss and P-H Hofschneider.