Genome Stability: From Virus to Human Application

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Igor Kovalchuk (Principle Investigator, Planet Biotechnology Laboratory, University of Lethbridge, Lethbridge, AB, Canada) Olga Kovalchuk (Principle Investigator, Human Epigenetics Laboratory, University of Lethbridge, Lethbridge, AB, Canada)

Genome Stability

From Virus to Human Application

Igor Kovalchuk (Principle Investigator, Planet Biotechnology Laboratory, University of Lethbridge, Lethbridge, AB, Canada), Olga Kovalchuk (Principle Investigator, Human Epigenetics Laboratory, University of Lethbridge, Lethbridge, AB, Canada)

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English

Academic Press Inc
22 July 2021

Genetics (non-medical); DNA & Genome

Series: Translational Epigenetics

Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging.

This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability.

Edited by: Igor Kovalchuk (Principle Investigator Planet Biotechnology Laboratory University of Lethbridge Lethbridge AB Canada), Olga Kovalchuk (Principle Investigator, Human Epigenetics Laboratory, University of Lethbridge, Lethbridge, AB, Canada)
Imprint: Academic Press Inc
Country of Publication: United Kingdom
Edition: 2nd edition
Dimensions: Height: 276mm, Width: 215mm,
Weight: 2.040kg
ISBN: 9780323856799
ISBN 10: 0323856799
Series: Translational Epigenetics
Pages: 760
Publication Date: 22 July 2021
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Dr. Igor Kovalchuk is the Principle Investigator in the Plant Biotechnology laboratory at the University of Lethbridge. His lab studies genetic and epigenetic regulation of plant response to stress as well as develops various methods for improvement of plant transformation. He is particularly interested in the transgenerational effects of stress and microevolution of plant stress tolerance/resistance.He has substantial expertise in plant stress tolerance and plant transgenesis. Dr. Olga Kovalchuk is the Principle Investigator of the Human Epigenetics laboratory at the University of Lethbridge. Her lab studies the role of epigenetic dysregulation in carcinogenesis, epigenetic regulation of the cancer treatment responses, radiation epigenetics and the role of epigenetic changes in genome stability and carcinogenesis, radiation-induced oncogenic signaling, and radiation-induced DNA damage, repair, and recombination.