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Academic Press Inc
24 April 2020
Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing.

Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.
Volume editor:   Diego A. Forero (Full Professor; Director Laboratory of Neuropsychiatric Genetics; Director PhD Program in Health Sciences School of Medicine Universidad Antonio Narino<br>Bogota Colombia), George P. Patrinos
Imprint:   Academic Press Inc
Country of Publication:   United States
Dimensions:   Height: 235mm,  Width: 191mm, 
Weight:   610g
ISBN:   9780128178195
ISBN 10:   0128178191
Series:   Translational and Applied Genomics
Pages:   288
Publication Date:   24 April 2020
Audience:   Professional and scholarly ,  Undergraduate
Format:   Paperback
Publisher's Status:   Active

Professor Forero is medical doctor, graduated from the National University of Colombia and did his PhD in Biomedical Sciences at the University of Antwerp (Belgium). Dr. Forero is Full Professor at the School of Medicine of the Universidad Antonio Narino (Bogota, Colombia), being the current leader of the Biomedical Sciences Research Group, Director of the Neuropsychiatric Genetics Laboratory and Director of the PhD Program in Health Sciences. He has led several research projects in molecular genetics of neurological and psychiatric disorders, in collaboration with national and international research groups. Dr Forero has authored publications in international scientific journals and books (cumulative impact factor of 223.267, h index: 22). He has been Associate Editor of BMC Research Notes, member of the editorial board of 3 international scientific journals and peer reviewer for 69 international scientific journals. George Patrinos is Professor of Pharmacogenomics at the University of Patras School of Health Sciences (Department of Pharmacy) in Patras, Greece with Adjunct positions in Rotterdam, the Netherlands and Al-Ain, United Arab Emirates. His research interests span the fields of pharmacogenomics and personalised medicine, focused on psychiatric diseases and hemoglobinopathies, the implementation of genomics into healthcare, particularly for health systems in developing countries, the development of genomic databases and web-based translational tools for personalised medicine and the application of genomics in public health. George Patrinos has published more than 270 scientific papers in peer reviewed journals on topics related to genetics, genomic medicine, pharmacogenomics, molecular diagnostics, and social and economic evaluation for genomic medicine. He is also the editor of several textbooks published by Elsevier/Academic Press, including the renowned textbook Molecular Diagnostics , published by Elsevier now in its third edition. He serves as Editor-In-Chief and Communicating and Associate Editor for several high impact scientific journals and he is co-organizer of the international meeting series Golden Helix Conferences .

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