Genome Plasticity in Health and Disease

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Diego A. Forero (Full Professor; Director, Laboratory of Neuropsychiatric Genetics; Director, PhD Program in Health Sciences, School of Medicine, Universidad Antonio Nariño,<br>Bogotá, Colombia) George P. Patrinos

Genome Plasticity in Health and Disease

Diego A. Forero (Full Professor; Director, Laboratory of Neuropsychiatric Genetics; Director, PhD Program in Health Sciences, School of Medicine, Universidad Antonio Nariño,<br>Bogotá, Colombia), George P. Patrinos

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English

Academic Press Inc
07 April 2020

Genetics (non-medical); DNA & Genome; Molecular biology

Series: Translational and Applied Genomics

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing.

Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.

Volume editor: Diego A. Forero (Full Professor; Director Laboratory of Neuropsychiatric Genetics; Director PhD Program in Health Sciences School of Medicine Universidad Antonio Nariño <br>Bogotá Colombia), George P. Patrinos
Imprint: Academic Press Inc
Country of Publication: United States
Dimensions: Height: 234mm, Width: 191mm,
Weight: 600g
ISBN: 9780128178195
ISBN 10: 0128178191
Series: Translational and Applied Genomics
Pages: 288
Publication Date: 07 April 2020
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

1. Impact of Genome Plasticity on Health and Disease Section I. Plasticity of the Human Genome2. Overview of the Human Genome3. Methods for Epigenomic Analyses: DNA Methylation4. Genomic Databases5. Genomic Variability: Germline, Somatic and de novo Variants6. Founder Variations in Isolated Populations7. DNA Methylation8. Chromatin, Histones and Histone Modifications in Health and Diseases9. Networks of Transcription Factors10. Centromere and Telomere Dynamics in Humans Section II. Human Genome Plasticity and Diseases11. Genome Plasticity and Cardiovascular Diseases12. Genome Plasticity and Neuropsychiatric Disorders13. Genome Plasticity and Endocrine Diseases14. Implications of Genome Plasticity for Drug Development

Professor Forero is medical doctor, graduated from the National University of Colombia and did his PhD in Biomedical Sciences at the University of Antwerp (Belgium). Dr. Forero is Full Professor at the School of Medicine of the Universidad Antonio Nariño (Bogotá, Colombia), being the current leader of the Biomedical Sciences Research Group, Director of the Neuropsychiatric Genetics Laboratory and Director of the PhD Program in Health Sciences. He has led several research projects in molecular genetics of neurological and psychiatric disorders, in collaboration with national and international research groups. Dr Forero has authored publications in international scientific journals and books (cumulative impact factor of 223.267, h index: 22). He has been Associate Editor of BMC Research Notes, member of the editorial board of 3 international scientific journals and peer reviewer for 69 international scientific journals. Dr. Patrinos is internationally renowned for his involvement in the field of pharmacogenomics research. His research includes discovery work and addresses the issue of clinical implementation of pharmacogenomics in a holistic manner, including wet- and dry-lab, as well as public health genomics approaches. Dr. Patrinos has also a keen interest in the clinical implementation of genomic medicine in resource-limited environments.