Epigenetics and DNA Damage

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Miriam Galvonas Jasiulionis (Professor, Department of Pharmacology and Scientist, Laboratory of Ontogeny and Epigenetics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil)

Epigenetics and DNA Damage

Miriam Galvonas Jasiulionis (Professor, Department of Pharmacology and Scientist, Laboratory of Ontogeny and Epigenetics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Brazil)

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English

Academic Press Inc
25 August 2022

Genetics (non-medical); DNA & Genome

Series: Translational Epigenetics

Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment.

Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

Edited by: Miriam Galvonas Jasiulionis (Professor Department of Pharmacology and Scientist Laboratory of Ontogeny and Epigenetics Escola Paulista de Medicina Universidade Federal de Sao Paulo Brazil)
Imprint: Academic Press Inc
Country of Publication: United Kingdom
Dimensions: Height: 235mm, Width: 191mm,
Weight: 680g
ISBN: 9780323910811
ISBN 10: 0323910815
Series: Translational Epigenetics
Pages: 336
Publication Date: 25 August 2022
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Dr. Miriam Galvonas Jasiulionis is a Professor at the Department of Pharmacology, in the Laboratory of Ontogeny and Epigenetics, at the Universidade Federal de São Paulo, Brazil. Her lab has investigated the role of epigenetic alterations in the relationship between sustained stressful conditions and malignant transformation, especially in melanocytes, to contribute to better comprehension of mechanisms involved in melanoma genesis and open avenues to develop novel therapeutic approaches. Dr. Jasiulionis has published widely in such peer reviewed journals as Clinical Epigenetics, Molecular Oncology, Frontiers in Immunology, Oncotarget, Epigenetics, and Neoplasia.

Reviews for Epigenetics and DNA Damage

"""Overall, I feel this is a great book for both investigators with no or limited experience in the field and for seasoned investigators planning to test a new hypothesis."" --Quarterly Review of Biology"