Epigenetic Therapy of Cancer

Preclinical Models and Treatment Approaches

Michael Lübbert, Peter A. Jones

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English

Springer-Verlag Berlin and Heidelberg GmbH & Co. K
24 September 2016

Oncology; Haematology; Gene therapy

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.

Edited by: Michael Lübbert, Peter A. Jones
Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
Country of Publication: Germany
Edition: Softcover reprint of the original 1st ed. 2014
Dimensions: Height: 235mm, Width: 155mm, Spine: 18mm
Weight: 5.095kg
ISBN: 9783662519288
ISBN 10: 3662519283
Pages: 325
Publication Date: 24 September 2016
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Reviews for Epigenetic Therapy of Cancer: Preclinical Models and Treatment Approaches

From the reviews: “This new book covers the timely topic of epigenetic therapy. … The combination of articles describing the basic science framework of epigenetics and the detailed summaries of clinical trials with epigenetic drugs is attractive for a wide readership, ranging from medical students to scientists who are interested in translational studies to clinicians who work for the direct benefit of cancer patients. … This high-quality book is an excellent overview of the current success and future promise of epigenetic therapy.” (Gerd Pfeifer, Doody’s Book Reviews, May, 2014)