Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ('vector') to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession.
This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system. Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.
Edited by:
Roland W Herzog (Univ Of Florida Usa),
Sergei Zolotukhin (Univ Of Florida,
Usa)
Imprint: World Scientific Publishing Co Pte Ltd
Country of Publication: Singapore
Dimensions:
Height: 232mm,
Width: 158mm,
Spine: 23mm
Weight: 762g
ISBN: 9789814280907
ISBN 10: 9814280909
Pages: 416
Publication Date: 21 June 2010
Audience:
College/higher education
,
Professional and scholarly
,
Further / Higher Education
,
Undergraduate
Format: Hardback
Publisher's Status: Unspecified
Non-Viral Vectors (S Sullivan); Adenoviral Vectors (A Baker); Retroviral Vectors and Integration Analysis (C von Kalle); Lentiviral Vectors (T VandenDriessche & M Chuah); Herpes Virus Vectors (J Glorioso); Adeno-Associated Viral (AAV) Vectors (N Muzyczka); Regulatory RNAs (Ribozymes, RNAi and miRNA) (A Lewin); Integrating Vectors (Transposon, Phage Integrase) (M Calos); Gene Correction Strategies/Zinc Fingers (M Porteus); Gene Switches (P Moullier); Gene Therapy for Disorders of the CNS (D Young); Hemoglobinopathies (A Srivastava); Severe Immune Deficiencies (A Aiuti); Hemophilia (R Herzog); Obesity and Diabetes (S Zolotukhin & C Wasserfall); Musculoskeletal Disorders (S Takeda); Cancer Gene Therapy (K Weigel-Van Aiken); Autoimmune Disorders (P Robbins); Lysosomal Storage Diseases (C Mah); Retinal Diseases (B Hauswirth); Pulmonary Diseases (T Flotte); Cardiovascular Diseases (B Byrne).
Reviews for Guide To Human Gene Therapy, A
A merciless killer meets his match in the hostage he's snatched from a nursing home in Morgenroth's white-hot debut. The man called Merec has killed, by his own count, 82 people, but he never tires of staging scenes that pose his victims' impossible moral dilemmas. His favorite game is to pair prospective victims off and ask one of each pair which of the two he should kill. One day he and his crew (Tina the inside contact, Jeremy the obliging videotaper, etc.) descend on the Willowridge Rest Home in Virginia. When they pair off the clients and the available staff, every person they ask tells them to kill the other half of the pair - every person but Sarah Shepherd. Sarah, widowed by a car crash four months earlier, has been hopelessly apathetic until Merec comes along, but the defining moment he poses, faithfully captured on video, gives her a new lease on life. Instead of killing her, he takes her hostage and has her beaten and tortured on camera with the idea that sooner or later she'll break down and make a videotaped plea for a $10 million ransom the public, fascinated by her endlessly televised story, will queue up to help pay. But Sarah's made of sterner stuff than Merec thinks. Not only does she refuse to snap; she refuses, when the chance offers, to escape, insisting that she'd rather enjoy whatever employment Merec can offer her than endure her brief talk-show stint as a hero before returning to idle despair. Though Morgenroth tacks on her share of action cliches - the heartlessly jokey chapter titles, the justice agencies hopelessly at odds with each other, the scheming media mogul, the prison-house testimony that labels Merec evil - her unsparing take on fame and morality in contemporary America gives this exhilarating tale an unsettling edge. The rat-tat-tat-tat delivery recalls Speed laced with moral conundrums. Just don't get too attached to any of the minor characters. (Kirkus Reviews)