Enzyme Kinetics in Drug Metabolism

Fundamentals and Applications

Swati Nagar, Upendra A. Argikar, Donald Tweedie

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English

Springer-Verlag New York Inc.
18 July 2022

Biochemistry; Enzymology

Series: Methods in Molecular Biology

Summary
Details

This second edition further develops the principles of applying kinetic principles to drug metabolizing enzymes and transporters. Chapters are divided into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting specific oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for drug metabolizing enzymes and transporters, understanding of variability both experimental and interindividual (pharmacogenomic), and expanded case studies that provide real life examples of applying these principles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, in some cases step-by-step instructions with readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning.

Authoritativeand fully updated, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition serves as a practical teaching tool for novice and advanced scientists interested in the fundamental concepts.

Edited by: Swati Nagar, Upendra A. Argikar, Donald Tweedie
Imprint: Springer-Verlag New York Inc.
Country of Publication: United States
Edition: Second Edition 2021
Volume: 2342
Dimensions: Height: 254mm, Width: 178mm,
Weight: 1.701kg
ISBN: 9781071615560
ISBN 10: 1071615564
Series: Methods in Molecular Biology
Pages: 881
Publication Date: 18 July 2022
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active