Dna Deamination And The Immune System

Aid In Health And Disease

Nina Papavasiliou , Sebastian Fugmann , Marilyn Diaz

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Hardback

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English

Imperial College Press
27 October 2010

Biochemistry; Biochemical immunology; Molecular biology

Series: Molecular Medicine And Medicinal Chemistry

Summary
Details

This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments.

Edited by: Nina Papavasiliou , Sebastian Fugmann , Marilyn Diaz
Imprint: Imperial College Press
Country of Publication: United Kingdom
Volume: 3
Dimensions: Height: 229mm, Width: 155mm, Spine: 23mm
Weight: 576g
ISBN: 9781848165922
ISBN 10: 1848165927
Series: Molecular Medicine And Medicinal Chemistry
Pages: 232
Publication Date: 27 October 2010
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Active