Cambridge Textbook of Neuroscience for Psychiatrists is a 'one stop shop' for what any psychiatrist needs to know about the brain. Understanding the brain and mind requires a vast array of techniques and conceptual approaches. The Editors have assembled a team of basic neuroscientists, geneticists, psychologists, psychiatrists, neurologists, neurosurgeons and endocrinologists who bring you the cutting edge of translational neuroscience that addresses the material most relevant to current or future psychiatric practice. The book showcases what is known, highlights aspects that are less well understood and defines key outstanding questions. A revolution in our understanding of the brain has, so far, done little to disrupt mainstream psychiatric practice. That is set to change. The chapters align with the UK MRCPsych neuroscience syllabus and link to the USA National Neuroscience Curriculum Initiative (NNCI). Highly illustrated and accessible, this book will appeal to psychiatrists, neuroscientists, psychologists, other healthcare students and professionals.
I. Cells: 1.1. Neurons; 1.2. The physiology of neurons, synapses and receptors; 1.3. Modelling single neurons and their combinations in circuits; 1.4. Glia; II. Neurotransmitters and Receptors: 2.1. The chemical synapse; 2.2. Classification of receptors: metabotropic and ionotropic receptors; 2.3. Neuronal receptors and drug targets; 2.4. Basic pharmacology of specific neurotransmitter pathways; 2.5. Neuropeptides; 2.6. Genetic association studies and neurotransmitter pathways; 2.7. Opioids and common recreational drugs; III. Basic Techniques in Neuroscience: 3.1. Recording from the brain; 3.2. Perturbing brain function; 3.3. Animal models of psychiatric disease; 3.4. Data analysis and computational modelling; 3.5. Functional neuroimaging and connectivity; IV. Neuroanatomy: 4.1. Fundamentals; 4.2. The basal ganglia; 4.3. The temporal lobes; 4.4. The frontal lobes; 4.5. White matter pathways; 4.6. Ascending neurotransmitter systems; V. Neural Circuits: 5.1. Appetite; 5.2. Sleep; 5.3. Sex and sex hormones; 5.4. Violence and aggression; 5.5. Nociception and pain; 5.6. The motor system and movement disorders; 5.7. Computational models of learning; 5.8. Habit formation; 5.9. Reward, pleasure and motivation; 5.10. Emotion; 5.11. Perception; 5.12. Attention; 5.13. Apathy, anhedonia and fatigue; 5.14. Memory; 5.15. Fronto-executive functions; 5.16. Empathy and theory of mind; 5.17. Language; 5.18. Brain networks and dysconnectivity; VI. Modulators: 6.1. The hypothalamic–pituitary (Neuroendocrine) axis; 6.2. The stress response and glucocorticoids; 6.3. Adrenal steroids; 6.4. Inflammation and immune responses; VII. Genetics: 7.1. Basic genetic principles and the history of gene identification; 7.2. Common variation; 7.3. Rare variation; 7.4. Epigenetics; 7.5. The clinical application of genetics in psychiatry; VIII. Neurodevelopment and Neuroplasticity: 8.1. The development of brain structure and function; 8.2. Neurodevelopmental models of psychiatric disorders; 8.3. Attachment; 8.4. Neuroplasticity; 8.5. Intelligence and intellectual disability; IX. Integrated Neurobiology of Specific Syndromes and Treatments: 9.1. Autism; 9.2. Attention deficit hyperactivity disorder; 9.3. Drug use, addiction, tolerance, withdrawal and relapse; 9.4. Anxiety disorders; 9.5. Post-traumatic stress disorder; 9.6. Obsessive–compulsive and related disorders; 9.7. Major depressive disorder; 9.8. Bipolar affective disorder; 9.9. Psychosis; 9.10. Schizophrenia; 9.11. Borderline personality disorder; 9.12. Self-harm and suicidality; 9.13. Medically unexplained symptoms; 9.14. Delirium; 9.15. Perinatal disorders; 9.16. Sleep disorders; 9.17. Eating disorders; 9.18. Epilepsy and seizures; 9.19. Electroconvulsive therapy; 9.20. Brain stimulation; X. Neurodegeneration: 10.1. A neurodegenerative cascade of causality; 10.2. Prodromal disease and mild cognitive impairment; 10.3. Preclinical stages of neurodegenerative disease; 10.4. Spectra, domains and dimensions of neurodegenerative disease; 10.5. Reserve, resilience and resistance to neurodegeneration; 10.6. Environmental causes of neurodegenerative disease; 10.7. Morbidity and dual pathology in neurodegenerative disorders.
Dr Mary-Ellen Lynall is a Clinical Lecturer in the Department of Psychiatry at the University of Cambridge. Professor Peter B. Jones is a Professor of Psychiatry at the Department of Psychiatry, University of Cambridge and honorary consultant psychiatrist, Cambridgeshire & Peterborough NHS Foundation Trust. Stephen M. Stahl is Professor of Psychiatry at the University of California, San Diego, USA and Honorary Visiting Senior Fellow in Psychiatry at the University of Cambridge, UK. Dr Stahl is the author of the bestsellers Stahl's Essential Psychopharmacology (2021) and The Prescriber's Guide (2021).
