Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Electrophysiological Methods for Recording CRAC and TRPV5/6 Channels J. Ashot Kozak and Grigori Rychkov Studies of Structure-Function and Subunit Composition of Orai/STIM Channel Marc Fahrner, Rainer Schindl, and Christoph Romanin Signaling ER Store Depletion to Plasma Membrane Orai Channels Aparna Gudlur and Patrick Hogan Modulation or Orai1 and STIM1 by Cellular Factors Jin Seok Woo, Sonal Srikanth, and Yousang Gwack CRAC Channels and Ca2+-Dependent Gene Expression Yi-Chun Yeh and Anant B. Parekh Function of Orai/STIM Proteins Studied in Transgenic Animal Models Masatsugu Oh-Hora and Xiuyuan Lu Assessing the Molecular Nature of the STIM1/Orai1 Coupling Interface Using FRET Approaches Yandong Zhou, Youjun Wang, and Donald L. Gill Optogenetic Approaches to Control Calcium Entry in Nonexcitable Cells Lian He, Qian Zhang, Yubin Zhou, and Yun Huang Regulation of Orai/STIM Channel Activities by pH Albert S. Yu, Zhichao Yue, Jianlin Feng, and Lixia Yue Non-Orai Partners of STIM Proteins: Role in ER-PM Communication and Ca2+ Signaling Klaus Groschner, Niroj Shrestha, and Nicola Fameli Store-Independent orai Channels Regulated by STIM Xuexin Zhang, Maxime Gueguinou, and Mohamed Trebak Regulation and Role of Store-Operated Ca2+ Entry in Cellular Proliferation Rawad Hodeify, Fang Yu, Raphael Courjaret, Nancy Nader, Maya Dib, Lu Sun, Ethel Adap, Satanay Hubrack, and Khaled Machaca TRPV5 and TRPV6 Calcium-Selective Channels Ji-Bin Peng, Yoshiro Suzucki, Gergely Gyimesi, and Matthias A. Hediger Determining the Crystal Structure of TRPV6 Kei Saotome, Appu K. Singh, and Alexander I. Sobolevsky Identifying TRP Channel Subunit Stoichiometry Using Combined Single Molecule Single Channel Determinations (SC-SMD) Laura G. Ceballos, Alexander Asanov, and Luis Vaca Pharmacology of Store-Operated Calcium Entry Channels Gary S. Bird and James W. Putney, Jr.
Ashot Kozak is Associate Professor of Neuroscience, Cell Biology and Physiology in the Department of Biological Sciences at Wright State University in Dayton, Ohio. He received his PhD from Mount Sinai School of Medicine and did a postdoc at the University of California, Irvine. His research focuses upon cation channels expressed in leukocytes; Transient Receptor Potential (TRP) channels; ion channels involved in nociception.