Bound Carbohydrates in Nature

Leonard Warren (The Wistar Institute of Anatomy and Biology, Philadelphia)

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English

Cambridge University Press
18 April 1994

Organic chemistry; Biochemistry; Carbohydrates

Series: Lezioni Lincee

This book is based on a series of six lectures delivered at the University of Sienna under the auspices of the Lezioni Lincee. The content of the book reflects and delineates the author's career in biochemical research. The lectures revolve around the special role which bound carbohydrates play in nature. Also discussed are the

properties of membrane glycoproteins, involved in the resistance of cells to drugs. The metabolism of sugars and sialic acids, which form a pivotal role in the author's research, are covered in detail. The book chronicles just some of the huge advances which have been made in biochemistry over the past few decades and will prove an invaluable and entertaining first hand account for researchers and graduate students.

By: Leonard Warren (The Wistar Institute of Anatomy and Biology Philadelphia)
Imprint: Cambridge University Press
Country of Publication: United Kingdom
Dimensions: Height: 216mm, Width: 140mm, Spine: 11mm
Weight: 310g
ISBN: 9780521442312
ISBN 10: 0521442311
Series: Lezioni Lincee
Pages: 126
Publication Date: 18 April 1994
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

1. Introduction, history, microheterogeneity of bound carbohydrates; function of bound carbohydrates; inducible changes in bound carbohydrates; programmed changes in bound carbohydrates; a possible role for bound carbohydrates; 2. Sialic acids; distribution of sialic acids in nature; the metabolism of hexamines and sialic acids; metabolic control of hexosamines and sialic acids; asparagine N-glycosylation; processing of lysomal enzymes; biosynthesis of O-linked oligosaccarides; modification of sialic acids; sialidases; genetic metabolic disorders involving sialic acids, glycosidases, bound carbohydrates in malignancy; 3. Multidrug resistance, properties of P-glycoprotein; lysomes and multidrug resistance; kinetics of influx and efflux of drugs, modulation of multidrug resistance; the role of lipids in the accumulation of drugs by MDR cells; P-170 and membrane lipids; Overview.