Antimalarial Natural Products

A. Douglas Kinghorn, Heinz Falk, Simon Gibbons , Yoshinori Asakawa

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English

Springer Nature Switzerland AG
05 January 2023

Organic chemistry; Biochemistry; Parasitology (non-medical)

Series: Progress in the Chemistry of Organic Natural Products

Summary
Details

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents.

Edited by: A. Douglas Kinghorn, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu
Imprint: Springer Nature Switzerland AG
Country of Publication: Switzerland
Edition: 2022 ed.
Volume: 117
Dimensions: Height: 235mm, Width: 155mm,
Weight: 197g
ISBN: 9783030898755
ISBN 10: 303089875X
Series: Progress in the Chemistry of Organic Natural Products
Pages: 106
Publication Date: 05 January 2023
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active