Xenobiotic Metabolic Enzymes

Bioactivation and Antioxidant Defense

Chang-Hwei Chen

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English

Springer Nature Switzerland AG
04 April 2021

Physiology; Pharmacology; Enzymology

This book provides a comprehensive, organized, and concise overview of xenobiotic metabolic enzymes and their health implications. The subjects addressed are broad in scope with an emphasis on recent advances in research on biochemical and biomedical aspects of these enzymes. The xenobiotics discussed include not just drugs, but also food, smoke, and other environmental chemicals. The subjects covered in this work include: metabolic enzymes and their catalyzed reactions, reactive intermediates generated from metabolic activation, oxidative stress mediated by electrophilic reactive intermediates, bioactivation - mediated cellular and functional damages, activation of Nrf2 – ARE pathway, genetic variations affecting metabolic enzyme expression, enzyme polymorphisms affecting xenobiotic - mediated toxicity, induction of metabolic enzymes for health benefits, and a diversity of metabolic enzyme modulators.

By: Chang-Hwei Chen
Imprint: Springer Nature Switzerland AG
Country of Publication: Switzerland
Edition: 2020 ed.
Dimensions: Height: 235mm, Width: 155mm,
Weight: 454g
ISBN: 9783030416812
ISBN 10: 303041681X
Pages: 239
Publication Date: 04 April 2021
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active

Dr. Chang-Hwei Chen is a biophysicist and professor emeritus of Biomedical Sciences at the School of Public Heath, University at Albany. He is currently a member of the Institute of Health and the Environment at the University at Albany.