X-ray Contrast Agent Technology: A Revolutionary History

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Christoph de Haen (Bracco Imaging SpA (Retired), University of Washington (Retired))

X-ray Contrast Agent Technology

A Revolutionary History

Christoph de Haen (Bracco Imaging SpA (Retired), University of Washington (Retired))

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English

CRC Press
22 April 2019

History of medicine; Radiography

This book documents the fascinating history of radiological techniques that use contrast agents. The text includes many of the fundamental documentary sources that bring to life the social and scientific background of the discoveries, the personalities of the discoverers, and implementation of new technologies. Such agents when used with X-rays allow clinicians to distinguish anatomical structures with nearly identical densities. Focus is on urological and angiographic uses of contrast agents.

Key selling features:

Documents and thoroughly references the history of contrast agent development Reviews the priority and importance of patents Discusses the role that important individual scientists and leading research institutions have played in technology development and implementation

By: Christoph de Haen (Bracco Imaging SpA (Retired) University of Washington (Retired))
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions: Height: 234mm, Width: 156mm,
Weight: 689g
ISBN: 9781138351646
ISBN 10: 1138351644
Pages: 326
Publication Date: 22 April 2019
Audience: College/higher education , Professional and scholarly , Primary , Undergraduate
Format: Hardback
Publisher's Status: Active

Contents Preface......................................................................................................................vii Acknowledgments......................................................................................................ix Author........................................................................................................................xi Chapter 1 Introduction...........................................................................................1 Chapter 2 Methodological Considerations.............................................................9 Historical and Sociological Perspectives..............................................9 Technological Innovation.................................................................... 13 The Analytical Model of Technology Genesis and Shaping............... 15 Chapter 3 Assembly of a Technological Vision for X-Ray Contrast Agents....... 33 Chapter 4 Uro-Angiographic Contrast Agents—The Holy Grail........................ 41 Technology Genesis Phase.................................................................. 41 History............................................................................................ 41 From Sodium Iodide to Uroselectan Sodium and Methiodal Sodium..................................................................... 41 Contrasting Historical Interpretations..................................... 103 The Dynamics of Technology Genesis......................................... 109 The Failure of One-Dimensional Reductionism...................... 109 Technical Knowledge from Interference of Different Knowledge Cultures................................................................ 113 Interference as Communication and Individuation of Knowledge............................................................................... 119 The Emergence of a Technological Vision.............................. 122 Synchronization and Interference............................................124 The Functions of the Technological Vision............................. 125 Technology Espousal and Resistance...................................... 125 Technology-Shaping Phase............................................................... 126 History.......................................................................................... 126 Perfecting Ionic Uro-Angiographic Contrast Agents.............. 126 The Controversial Prehistory of Nonionic Contrast Agents....... 156 Nonionic Contrast Agents........................................................ 170 The Dynamics of Technology Shaping........................................ 211 The Failure of One-Dimensional Reductionism...................... 211 Technical Knowledge from Interference of Different Knowledge Cultures................................................................ 215 Interference as Communication and Individuation of Knowledge............................................................................... 221 The Emergence of a Technological Vision..............................224 Synchronization and Interference............................................227 The Function of the Technological Vision..............................228 Technology Espousal and Resistance......................................228 Technology Consolidation and Economization Phase......................229 History..........................................................................................229 The Search for a New Vision........................................................ 235 Chapter 5 Conclusions....................................................................................... 239 References.............................................................................................................. 247 Endnote..................................................................................................................287 Person Index..........................................................................................................307 Subject Index......................................................................................................... 317

Christoph de Haën, born September 9, 1940 in Switzerland, studied chemistry and biology in Lausanne, Zurich, and Rome, earning a master’s degree in chemistry from the Swiss Federal Institute of Technology (ETH Zurich), followed by a PhD in molecular biology at the same institution. After a postdoctoral fellowship in biochemistry at the University of Washington, Seattle, he became research faculty at the same institution, jointly appointed in the Departments of Medicine (Division of Endocrinology and Metabolism) and Biochemistry. There he moved up the ranks to Research Full Professor and Graduate Faculty. In mid-career he joined the Bracco company, a worldwide active pharmaceutical corporation, headquartered in Milan, Italy. There he held various leadership positions in global research and development, including Head of the Milano Research Center and Scientific Advisor to the Bracco Group of Companies. The principle field of activity was contrast agents for various diagnostic imaging modalities. His publications span a wide variety of fields, including social science ones. He retired in 2005 and lives in Switzerland.

Reviews for X-ray Contrast Agent Technology: A Revolutionary History

This book, written by the eminent chemist and former scientific adviser to Bracco, covers the history of x-ray contrast agents concentrating primarily on uroangiographic agents. The contributions of the giants in this field, such as Lichtenberg, Swick and of course Almen, are covered in considerable depth. - Dr. Arpan K Banerjee, past chair and trustee, British Society for the History of Radiology