Voltage-Gated Calcium Channels

Gerald Werner Zamponi, Norbert Weiss

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English

Springer International Publishing AG
09 November 2022

Physiology; Pharmacology; Biophysics; Neurosciences; Cellular biology (cytology)

This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calciumchannel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.

Edited by: Gerald Werner Zamponi, Norbert Weiss
Imprint: Springer International Publishing AG
Country of Publication: Switzerland
Edition: 2022 ed.
Dimensions: Height: 254mm, Width: 178mm,
Weight: 1.533kg
ISBN: 9783031088803
ISBN 10: 3031088808
Pages: 710
Publication Date: 09 November 2022
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Preface: History of VGCCs STRUCTURAL AND MOLECULAR ASPECTS OF VGCCS 1. Measuring and manipulating calcium 2. Structure, function and subunit assembly of VGCC 3. Splice variation and RNA editing of VGCCs 4. Mechanisms of calcium channel permeation 5. Regulation by beta subunits 6. Regulation by alpha2 delta subunits 7. VGCCs in invertebrates REGULATION OF VGCCS 8. Modulation by GPCRs and second messengers 9. Trafficking of VGCCs 10. Calcium regulation 11. Calcium channel complexes with other channels 12. Regulation of gene transcription by VGCCs (PATHO)PHYSIOLOGY OF VGCCS 13. Lessons from knock-out and knock-in mice 14. VGCCs and synaptic transmission 15. Cardiovascular syste 16. Calcium channels and exocytosis in chromaffin cells 17. Calcium channels in the pancreas in health and disease 18. Skeletal muscle system 19. Auditory and visual systems 20. Calcium channels and pain transmission 21. Migraine 22. Epilepsy 23. Psychiatric disorders 24. Parkinson’s disease 25. Reproductive system 26. Cancer PHARMACOLOGY OF VGCCS 27. Molecular determinants of VGCC pharmacology 28. Interactions with peptide toxins 29. Clinical pharmacology and drug discovery

Dr. Gerald Werner Zamponi is a Professor in the Department of Physiology and Biophysics, and Canada Research Chair in Molecular Neuroscience, at the University of Calgary, Calgary, Canada. Dr. Norbert Weiss is an Assistant Professor in the Department of Pathophysiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.