A groundbreaking piece of work, Virus Therapy of Human Cancers surveys possible research pathways for the treatment of human cancer and examines the regression of tumors in virally-infected patients. This text inspects the rational development of oncolytic viruses through genetic modification of influenza A viruses, lists more than fifty oncolytic adenovirus preparations, and assesses the engineering of these viruses acting in tumor cells with eliminated or disabled RB or r53. Featuring the contributions of nearly thirty leading authorities in their field through personal narrative accounts, illustrations and case studies, this is a worthwhile companion for anyone interested or working in this area.
Edited by:
Joseph G. Sinkovics,
Joseph Horvath
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions:
Height: 229mm,
Width: 152mm,
Spine: 42mm
Weight: 1.270kg
ISBN: 9780824759131
ISBN 10: 0824759133
Pages: 848
Publication Date: 28 December 2004
Audience:
College/higher education
,
Professional and scholarly
,
Primary
,
Undergraduate
Format: Hardback
Publisher's Status: Active
Introduction o Progressive Development of the Viral Therapy of Human Cancers: A Personal Narrative Account Joseph G. Sinkovics o New Biological Therapeutics: Competitors or Collaborators in Viral Therapy for Human Cancers Joseph G. Sinkovics o Naturally Oncolytic Viruses o Measles Virus: Improving Natural Oncolytic Properties by Genetic Engineering Christoph Springfield, Adele Fielding, Kah-Whye Peng, Eva Galanis, Stephen J. Russell, and Roberto Cattaneo o Newcastle Disease Virus: Anti-tumor Immune Memory and Its Activation for Control of Residual Tumor Cells and Improvement of Patient Survival Volker Schirrmacher o Newcastle Disease Virus: Its Oncolytic Properties Joseph C. Horvath o Influenza A Viruses with Deletions in the NS1 Gene: A Rational Approach to Develop Oncolytic Viruses Michael Bergmann and Thomas Muster o Vesicular Stomatitis Virus: An Oncolytic Agent Rebecca A. C. Taylor, Jennifer M. Paterson, and John C. Bell o Parvoviruses as Anti-Cancer Agents Jean Rommelaere, Nathalia Giese, Celina Cziepluch, and Jan J. Cornelis o Viral Oncolysates o Newcastle Disease Virus Oncolysate in the Management of Stage III (AJCC) Malignant Melanoma William A. Cassel, Douglas R. Murray, and Zbigniew L. Olkowski o Vaccinia Viral Lysates in Immunotherapy of Melanoma Peter Hersey o Genetically Engineered Oncolytic Viruses o Fusogenic Oncolytic Herpes Simplex Viruses for Therapy of Solid Tumors Xinping Fu, Mikihito Nakamori, and Xiaoliu Zhang o Poliovirus Recombinants Against Malignant Glioma Melinda Merrill, David Solecki, and Matthias Gromeier o Oncolytic Viruses that Depend on Loss of RB or p53 Frank McCormick
Joseph G. Sinkovics , Joseph C. Horvath
