Vascular Disease, Alzheimer's Disease, and Mild Cognitive Impairment

A 'must-read,' very timely, comprehensive interdisciplinary overview illuminating the complexity of the dementia syndromes, particularly Vascular-Alzheimer spectrum disorders. -Sandra E. Black, Professor of Medicine (Neurology), Department of Medicine, Sunnybrook HSC and University of Toronto This remarkable volume brings us the most current understanding on the undeniable role of vascular disease risk factors in both neurodegenerative and vascular dementias. Expert authors fittingly also focus on prodromal phases of the most common dementia types including mild cognitive impairment and vascular cognitive impairment. They highlight vascular disease that robustly influences relevant neuropsychological, neuroimaging as well as neuropathological substrates of dementia syndromes. -Raj Kalaria, Professor of Cerebrovascular Pathology (Neuropathology), Newcastle University There is an increasing realization that the most common neuropathology underlying dementia and MCI is the combination of plaques, tangles, as well as alterations due to vascular disease. In this important book Libon, Lamar, Swenson, and Heilman have assembled an impressive set of contributors to describe the mechanisms, markers, and treatment implications of combined AD and vascular pathology commonly present in dementia and MCI. This endeavor stands to advance our knowledge and shift current research and clinical paradigms that study neurodegenerative illness. -Glenn Smith, Chair of Psychology, University of Florida In this book, world-leaders in the area summarize current knowledge on the heterogeneity of Alzheimer's disease, vascular dementia, and mild cognitive impairment, and how these conditions are on a continuum and influence and shape the expression of each other. This book is a must for researchers, clinicians, and others interested in the heterogeneity and overlap of the most common forms of cognitive decline, and will be a standard reference for many years. -Ingmar Skoog, Professor, Institute of Neuroscience and Physiology and Director of the Centre for Ageing and Health, AgeCap, University of Gothenburg, Sweden