In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.
Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others.
Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.
Contributors ix Introduction 1 Yehuda Shoenfeld, Nancy Agmon-Levin and Lucija Tomljenovic Part I: Mosaic of Autoimmunity 1 Role of Adjuvants in Infection and Autoimmunity 11 Eitan Israeli, Miri Blank, and Yehuda Shoenfeld 2 Infections as Adjuvants for Autoimmunity: The Adjuvant Effect 25 Quan M. Nhu and Noel R. Rose 3 Experimental Models of Adjuvants 35 Nicola Bassi, Mariele Gatto, Anna Ghirardello, and Andrea Doria 4 Answers to Common Misconceptions Regarding the Toxicity of Aluminum Adjuvants in Vaccines 43 Lucija Tomljenovic and Christopher A. Shaw 5 Allergy and Autoimmunity Caused by Metals: A Unifying Concept 57 Vera Stejskal 6 Genetics and Vaccinology 65 John Castiblanco and Juan-Manuel Anaya 7 Silicone and Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) 79 Yair Levy and Rotem Baytner-Zamir 8 Silicone Breast Implants and Autoimmune/Inflammatory Syndrome induced by Adjuvants (ASIA): A Literature Search 87 Elisabetta Borella, Eitan Israeli, and Yehuda Shoenfeld 9 Autoantibodies Induced by Vaccine 93 Nataša Toplak and Tadej Av¢§cin 10 The ASIA Syndrome Registry 103 Ignasi Rodriguez-Pinto and Yehuda Shoenfeld 11 Vaccination in Autoimmune Diseases 107 Carla Goncalves, Schahin Saad, Clovis A. Silva, and Eloisa Bonfa 12 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases 113 Abdulla Watad, Alessandra Soriano, and Yehuda Shoenfeld Part II: Studies on Autoimmune Conditions Induced by Vaccination 13 Measles, Mumps, and Rubella Vaccine: A Triad to Autoimmunity 129 Carlo Perricone, Guido Valesini, and Yehuda Shoenfeld 14 Yellow Fever Vaccine and Autoimmunity 135 Roger A. Levy and Rodrigo Poubel V. Rezende 15 Antiphospholipid Syndrome and Vaccines 141 Miri Blank and Paola Cruz-Tapias 16 Hepatitis B Vaccination and Autoimmunity 147 Daniel S. Smyk, Lazaros I. Sakkas, Yehuda Shoenfeld, and Dimitrios P. Bogdanos 17 Adverse Reactions to Human Papillomavirus Vaccines 163 Lucija Tomljenovic and Christopher A. Shaw 18 Influenza Vaccine and Autoimmune Diseases 175 Luis J. Jara, Gabriela Medina, Pilar Cruz Dominguez, Olga Vera-Lastra, Miguel A. Saavedra, Monica Vazquez del Mercado, and Minoru Satoh 19 Vaccines and Autoimmunity: Meningococcal Vaccines 185 Giovanna Passaro, Alessandra Soriano, and Raffaele Manna 20 Pneumococcal Vaccines and Autoimmune Phenomena 191 Elisabetta Borella, Nancy Agmon-Levin, Andrea Doria, and Yehuda Shoenfeld 21 BCG and Autoimmunity 197 Luigi Bernini, Carlo Umberto Manzini, and Clodoveo Ferri Part III: Autoimmune Diseases Solicited by Vaccination 22 Systemic Lupus Erythematosus Induced by Vaccines 209 Nurit Katz-Agranov and Gisele Zandman-Goddard 23 Vasculitides 223 Alessandra Soriano, Rotem Inbar, Giovanna Passaro, and Raffaele Manna 24 Vaccinations in Rheumatoid Arthritis 233 Eitan Giat and Merav Lidar 25 Undifferentiated Connective-Tissue Diseases 247 Maria Martinelli, Carlo Perricone, and Yehuda Shoenfeld 26 Vaccines, Infections, and Alopecia Areata 255 Yaron Zafrir, Sharon Baum, Nancy Agmon-Levin, and Yehuda Shoenfeld 27 Aluminum Particle Biopersistence, Systemic Transport, and Long-Term Safety: Macrophagic Myofasciitis and Beyond 261 Romain K. Gherardi, Josette Cadusseau, and Francois-Jerome Authier 28 Immune Thrombocytopenic Purpura: Between Infections and Vaccinations 271 Carlo Perricone, Maurizio Rinaldi, Roberto Perricone, and Yehuda Shoenfeld 29 Vaccinations and Type 1 Diabetes 283 Alessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ele Ferrannini, and Poupak Fallahi 30 Narcolepsy and H1N1 vaccine 291 María -Teresa Arango, Shaye Kivity, Nancy Agmon-Levin, Gili Givaty, Joab Chapman, and Yehuda Shoenfeld 31 Non-nutritional Environmental Factors Associated with Celiac Disease: Infections and Vaccinations 301 Aaron Lerner 32 Polymyalgia Rheumatica 307 Alessandra Soriano and Raffaele Manna 33 Acute Disseminated Encephalomyelitis: Idiopathic, Post-infectious, and Post-vaccination 311 Dimitrios Karussis and Panayiota Petrou 34 Fibromyalgia, Chronic Fatigue, Functional Disorders, and Vaccination: Where Do We Stand? 331 Jacob N. Ablin and Dan Buskila 35 Bullous Dermatoses, Infectious Agents, and Vaccines 337 Yaron Zafrir, Nancy Agmon-Levin, and Sharon Baum 36 Infections, Vaccinations, and Chronic Fatigue Syndrome 345 Hussein Mahagna, Naim Mahroum, and Howard Amital 37 Myositis and Vaccines 349 Ignasi Rodriguez-Pinto and Yehuda Shoenfeld Index 359
Yehuda Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair of Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University in Tel Aviv, Israel. He is also Founder of the Center for Autoimmune Diseases, both at the Sheba Medical Center in Tel Hashomer, Israel. Nancy Agmon-Levin is a specialist in Clinical Immunology and Allergology, and serves as Deputy Head of the Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center in Tel Hashomer, Israel. She is also President of the Israel Association for Allergy and Clinical Immunology (IAACI). Lucija Tomljenovic is a Senior Postdoctoral Fellow in the Neural Dynamics Research Group at the University of British Columbia in Vancouver, BC, Canada.
