A comprehensive overview of clinically important infections of the urinary tract Urinary tract infections (UTIs) continue to rank among the most common infectious diseases of humans, despite remarkable progress in the ability to detect and treat them. Recurrent UTIs are a continuing problem and represent a clear threat as antibiotic-resistant organisms and infection-prone populations grow.
Urinary Tract Infections: Molecular Pathogenesis and Clinical Management brings the scientific community up to date on the research related to these infections that has occurred in the nearly two decades since the first edition. The editors have assembled a team of leading experts to cover critical topics in these main areas:
clinical aspects of urinary tract infections, including anatomy, diagnosis, and management, featuring chapters on the vaginal microbiome as well as asymptomatic bacteriuria, prostatitis, and urosepsis the origins and virulence mechanisms of the bacteria responsible for most UTIs, including uropathogenic Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae the host immune response to UTIs, the rise of antibiotic-resistant strains, and the future of therapeutics
This essential reference serves as both a resource and a stimulus for future research endeavors for anyone with an interest in understanding these important infections, from the classroom to the laboratory and the clinic.
If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow.
By:
MA Mulvey,
David J. Klumpp,
Ann E. Stapleton
Imprint: American Society for Microbiology
Country of Publication: United States
Edition: 2nd Edition
Dimensions:
Height: 259mm,
Width: 179mm,
Spine: 38mm
Weight: 1.630kg
ISBN: 9781555817398
ISBN 10: 1555817394
Pages: 676
Publication Date: 01 February 2017
Audience:
General/trade
,
College/higher education
,
ELT Advanced
,
Primary
Format: Hardback
Publisher's Status: Active
Contributors ix Foreword xvii Preface xix I. Clinical Aspects of Urinary Tract Infections 1 Anatomy and Physiology of the Urinary Tract: Relation to Host Defense and Microbial Infection 3 Duane R. Hickling, Tung-Tien Sun, and Xue-Ru Wu 2 Clinical Presentations and Epidemiology of Urinary Tract Infections 27 Suzanne E. Geerlings 3 Diagnosis, Treatment, and Prevention of Urinary Tract Infection 41 Paula Pietrucha-Dilanchian and Thomas M. Hooton 4 Urinary Tract Infections in Infants and Children 69 Theresa A. Schlager 5 The Vaginal Microbiota and Urinary Tract Infection 79 Ann E. Stapleton 6 Asymptomatic Bacteriuria and Bacterial Interference 87 Lindsay E. Nicolle 7 Bacterial Prostatitis: Bacterial Virulence, Clinical Outcomes, and New Directions 121 John N. Krieger and Praveen Thumbikat 8 Urosepsis: Overview of the Diagnostic and Treatment Challenges 135 Florian M. E. Wagenlehner, Adrian Pilatz, Wolfgang Weidner, and Kurt G. Naber II. Origins and Virulence Mechanisms of Uropathogenic Bacteria 9 Reservoirs of Extraintestinal Pathogenic Escherichia coli 161 Amee R. Manges and James R. Johnson 10 Origin and Dissemination of Antimicrobial Resistance among Uropathogenic Escherichia coli 179 Lisa K. Nolan, Ganwu Li, and Catherine M. Logue 11 Population Phylogenomics of Extraintestinal Pathogenic Escherichia coli 207 Jerome Tourret and Erick Denamur 12 Virulence and Fitness Determinants of Uropathogenic Escherichia coli 235 Sargurunathan Subashchandrabose and Harry L. T. Mobley 13 Uropathogenic Escherichia coli-Associated Exotoxins 263 Rodney A. Welch 14 Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria 277 Peter Chahales and David G. Thanassi 15 Pathoadaptive Mutations in Uropathogenic Escherichia coli 331 Evgeni Sokurenko 16 Invasion of Host Cells and Tissues by Uropathogenic Bacteria 359 Adam J. Lewis, Amanda C. Richards, and Matthew A. Mulvey 17 Proteus mirabilis and Urinary Tract Infections 383 Jessica N. Schaffer and Melanie M. Pearson 18 Epidemiology and Virulence of Klebsiella pneumoniae 435 Steven Clegg and Caitlin N. Murphy 19 Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract 459 Kimberly A. Kline and Amanda L. Lewis 20 Integrated Pathophysiology of Pyelonephritis 503 Ferdinand X. Choong, Haris Antypas, and Agneta Richter-Dahlfors III. Host Responses to Urinary Tract Infections and Emerging Therapeutics 21 Susceptibility to Urinary Tract Infection: Benefits and Hazards of the Antibacterial Host Response 525 Ines Ambite, Karoly Nagy, Gabriela Godaly, Manoj Puthia, Bjoern Wullt, and Catharina Svanborg 22 Innate Immune Responses to Bladder Infection 555 Byron W. Hayes and Soman N. Abraham 23 Host Responses to Urinary Tract Infections and Emerging Therapeutics: Sensation and Pain within the Urinary Tract 565 Lori A. Birder and David J. Klumpp 24 Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections 589 Valerie P. O'Brien, Thomas J. Hannan, Hailyn V. Nielsen, and Scott J. Hultgren Index 647
Reviews for Urinary Tract Infections - Molecular Pathogenesis and Clinical Management 2e
The editors of this tour de force of urinary tract biology have recruited the field???s top thought leaders to contribute chapters covering all aspects of the discipline. This outstanding text encompasses everything from the newest theories regarding basic pathogenesis of urinary tract infections, to broad insights into the epidemiology of bacterial uropathogens, and the latest in translational research on new vaccine and therapeutic candidates. -Michael Hsieh, MD, PhD, Stirewalt Endowed Director, Biomedical Research Institute; PI, Schistosomiasis Resource Center and The Bladder Immunology Group (BIG); Associate Professor of Urology and Pediatrics, George Washington University; Director, CAPITUL, Children???s National Medical Center
