Urea Transporters

Principle and Function of Urea Transport

Baoxue Yang, Jeff M. Sands

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English

Springer Nature Switzerland AG
11 July 2025

Physiology; Medical genetics

Series: Subcellular Biochemistry

This book intends to report the new progress of studies on urea transporters. The mechanisms and physiological functions of urea transporters across biological membranes are subjects of long-standing interests. Although urea represents roughly 40% of all urinary solutes in normal human urine, the handling of urea in the tissues has been largely neglected in the past and few clinical or experimental studies report data on urea. Unlike recent physiological books that mostly focus on water and electrolyte physiology，the aim of this book is to stimulate further research in new directions by providing novel and provocative insights into the further mechanisms and physiological significance of urea transport in mammals. This book offers a state-of-the-art report on recent discoveries concerning urea transport and where the field is going. It mainly focuses on advances made over the past 30 years on the genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. It will help graduate students and researchers to get an overall picture of mammalian urea transporters and may also yield benefits for pharmaceutical companies with regard to drug discovery based on the urea transporter.

This is the 2nd edition of the book. It builds upon the foundational insights of the previous edition, featuring expands content with new chapters and updated chapters to deepen understanding of urea transporters' mechanisms, functions, and significance, reflecting the latest advancements in this research area.

Edited by: Baoxue Yang, Jeff M. Sands
Imprint: Springer Nature Switzerland AG
Country of Publication: Switzerland
Edition: Second Edition 2025
Volume: 118
Dimensions: Height: 235mm, Width: 155mm,
ISBN: 9789819668977
ISBN 10: 9819668972
Series: Subcellular Biochemistry
Pages: 228
Publication Date: 11 July 2025
Audience: Professional and scholarly , College/higher education , Undergraduate , Further / Higher Education
Format: Hardback
Publisher's Status: Active

Chapter 1. Genes and Evolution of Urea Transporters.- Chapter 2. Protein Structures of Urea Transporters.- Chapter 3. Tissue Distribution, Expression and Regulation of Urea Transporters.- Chapter 4. Biochemical Modification and Subcellular Trafficking of Urea Transporters.- Chapter 5. Transport Characteristics of Urea Transporters.- Chapter 6. Physiological Functions of Urea Transporters.- Chapter 7. Urea Transporters and their gene mutations in diseases.- Chapter 8. Small-Molecule Inhibitors and Drug Discovery of Urea Transporters.- Chapter 9. Urea Transport Mediated by Membrane Proteins of Non-urea-Transporters.- Chapter 10. Energy-dependent urea transports in mammals and their functional consequences.

Baoxue Yang is the Professor and Chair of the Department of Pharmacology at Peking University. Prof. Yang has been studying urea transporters, including molecular biology, physiology, structural biology, pharmacology, etc., since 1997. He has published more than 170 original research articles in related fields. His H-factor is 52. Jeff M. Sands is the Juha P. Kokko Professor of Medicine and Physiology, Director of the Renal Division, and Executive Vice-Chair of the Department of Medicine at Emory University School of Medicine. Dr. Sands' research focuses on urea transport proteins and the urine concentrating mechanisms.