Understanding ME/CFS & Strategies for Healing

Patrick Ussher, Prof Klaus Wirth

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English

Patrick Ussher
31 January 2025

Immunology; Musculoskeletal medicine; Coping with illness; Complementary therapies, healing & health

If you live with relentless exhaustion, post-exertional malaise (PEM), brain fog, or ""normal"" test results that explain nothing, this book will finally help you understand what's really going on.

Millions with ME/CFS, Long Covid, and post-viral fatigue are told their symptoms are a mystery. But emerging research may at last reveal the underlying mechanisms - and offer a path toward meaningful improvement.

In this clear, direct, and deeply hopeful guide, ME/CFS patient Patrick Ussher explains the breakthrough model proposed by Professors Klaus Wirth and Carmen Scheibenbogen. Their work brings together the major abnormalities seen in ME/CFS - low blood volume, microclots, autonomic dysfunction, mitochondrial impairment, autoimmunity, and more - into one interconnected cycle.

It may finally explain why activity triggers PEM, why rest doesn't restore energy, and why so many develop chronic fatigue after a viral illness.

This book goes far beyond theory. It offers practical tools, science-based insights, and real-world strategies that patients use to manage symptoms and improve quality of life.

Inside, you'll learn about:

Breathing techniques to improve oxygenation Ancestral nutrition and gut repair Microclot-oriented treatment approaches Blood-washing procedures (HELP Apheresis & Immunoadsorption) The Perrin Technique The strengths and limits of neuroplasticity (""brain retraining"") Pacing, PEM management, and mitochondrial support The promising potential ""Mitodicure"" medication - the first drug candidate in development specifically for ME/CFS

Patrick also shares his own ME/CFS journey with honesty and clarity: what has helped him, what has not, and how he learned to navigate a misunderstood illness with both realism and hope.

If you live with:

ME/CFS Long Covid post-viral fatigue dysautonomia / POTS unexplained fatigue with normal blood tests

...this book will give you a clear framework for understanding your symptoms and practical strategies that may help you feel better.

Straightforward. Evidence-based. Patient-centred.

A guide for anyone seeking answers to this - up until now - most 'mysterious' of illnesses.

Includes a foreword by Prof. Klaus Wirth, co-developer of the Mitodicure therapy.

By: Patrick Ussher, Prof Klaus Wirth
Imprint: Patrick Ussher
Dimensions: Height: 229mm, Width: 152mm, Spine: 23mm
Weight: 585g
ISBN: 9782959831003
ISBN 10: 2959831004
Pages: 442
Publication Date: 31 January 2025
Audience: General/trade , ELT Advanced
Format: Paperback
Publisher's Status: Active

Patrick Ussher is a writer, composer, and health communicator who has lived with ME/CFS for seven years. He runs the YouTube channel 'Understanding ME/CFS', where he explores the science of ME/CFS and Long Covid in accessible language and shares personal insights into treatment strategies he has tried. He is the author of the medical hypothesis 'The Myth of Primary Polydipsia', which argues against the concept of 'psychogenic water drinking' and suggests a biomedical basis for thirst in ME/CFS and related illnesses.Patrick regularly gives talks to patient organizations such as The Irish ME Trust and has contributed essays to the ME/CFS blog Health Rising on a range of topics.Outside of health advocacy, Patrick is the author of 'Stoicism and Western Buddhism: A Reflection on Two Philosophical Ways of Life', and the editor of the books 'Stoicism Today: Selected Writings' (Volumes One and Two). In 2018, he worked with Columba Press to republish his late mother's book on coping with breast cancer, 'Following the Pink Ribbon Path'.He holds a BA and MA in Classics from the University of Exeter and is also a composer of contemporary classical music, with tracks available on Spotify and the Artlist catalogue. Originally from Ireland, Patrick has lived in both Ireland and France during his illness. Prof. Dr. Klaus Wirth, Medical Doctor, PhD, has served as Chief Scientific Officer and Managing Director of Mitodicure since 2022. He was previously Senior Researcher at Sanofi in Germany which he joined in 1984. Klaus worked as a pharmacologist in the fields of cardiovascular, bradykinin antagonism, cerebral blood flow, stroke, heart failure, arrhythmias, sodium-calcium exchanger NCX blockers, endocrinology, diabetes, obstructive sleep apnea, dysphagia, and immunology. Approximately 70 patents are attributable to his work, as well as five clinical developmental projects, one of which Firazyr(TM), a drug for the treatment of acute attacks of hereditary angioedema, has reached the market. Klaus was co-founder of KOSA Pharma GmbH. He is adjunct professor at the Institute of Pharmacology at Goethe University Frankfurt, Germany.

Reviews for Understanding ME/CFS & Strategies for Healing

'I have been strongly impressed by the high scientific level of Patrick's writings on ME/CFS, particularly considering his non-medical background and the short time that he could have worked on this area. I welcome the publication of his book which seeks particularly to explain the research by myself and Prof. Scheibenbogen in an accessible way for a patient audience, as well as talking about other facets of the illness and ways to improve quality of life.' Prof. Klaus Wirth - from the Foreword. "" In Understanding ME/CFS & Strategies for Healing, Patrick Ussher skillfully integrates a huge amount of research that at first glance looks unrelated. From it, he communicates a unique and compelling hypothesis about what is going on in ME/CFS and how to recover. Ussher supplements the science with his own personal journey of improvement and that of other patients. Understanding ME/CFS is a respectful, balanced and very readable book for both practitioners and lay readers"". Dr. Eleanor Stein MD FRCP(C), Canadian physician with 35+ years-experience in the field and former ME/CFS patient. Online educator for ME/CFS and related illnesses. "" I wholeheartedly recommend this book to anyone seeking to enhance their quality of life or to better understand possible pathways to improvement for conditions like ME/CFS, Long COVID, or other post-acute infection syndromes. Patrick Ussher's work is a beacon of hope, offering both scientific understanding and tangible solutions for those in need."" Prof. Peter Deen, Professor in Metabolic Physiology of the Radboud university, Nijmegen, The Netherlands and CEO of Streasure4Health, a start-up developing diagnostics for ME/CFS, Long Covid and Other Post-Acute Infection Syndromes 'I had many light bulb moments reading this book and would highly recommend it for those living with ME/CFS or Long Covid, their families, carers and health professionals. For those with cognitive dysfunction, the chapter summaries are also extremely helpful to refer to.' Julie Taylor, The Living with Long Covid Podcast 'Understanding ME/CFS & Strategies for Healing offers one patient's view through the long grass which has grown around an illness badly served by medical dogmatists, and it is a view which readers have much to learn from. It could herald a sea change in how ME/CFS is researched, managed, treated... and, just possibly, cured.' George Winter, The Medical Independent