Toxicology and Epigenetics

Saura C. Sahu (From Genomics to In Vitro and In Vivo Models)

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English

John Wiley & Sons Inc
14 September 2012

Genetics (non-medical); Toxicology (non-medical)

Epigenetics is the study of both heritable and non-heritable changes in the regulation of gene activity and expression that occur without an alteration in the DNA sequence. This dynamic and rapidly developing discipline is making its impact across the biomedical sciences, in particular in toxicology where epigenetic differences can mean that different individuals respond differently to the same drug or chemical.

Toxicology and Epigenetics reflects the multidimensional character of this emerging area of toxicology, describing cutting-edge molecular technologies to unravel epigenetic changes, the use of in vivo and in vitro models, as well as the potential use of toxicological epigenetics in regulatory environments. An international team of experts consider the interplay between epigenetics and toxicology in a number of areas, including environmental, nutritional, pharmacological, and computational toxicology, nanomaterials, proteomics and metabolomics, and cancer research.

Topics covered include:

environment, epigenetics and diseases DNA methylation and toxicogenomics chromatin at the intersection of disease and therapy epigenomic actions of environmental arsenicals environment, epigenetics and cardiovascular health toxicology, epigenetics and autoimmunity ocular epigenomics: potential sites of environmental impact in development and disease nuclear RNA silencing and related phenomena in animals epigenomics – impact for drug safety sciences methods of global epigenomic profiling transcriptomics: applications in epigenetic toxicology

Toxicology and Epigenetics is an essential insight into the current trends and future directions of research in this rapidly expanding field for investigators, toxicologists, risk assessors and regulators in academia, industry and government.

Edited by: Saura C. Sahu (From Genomics to In Vitro and In Vivo Models)
Imprint: John Wiley & Sons Inc
Country of Publication: United States
Dimensions: Height: 254mm, Width: 197mm, Spine: 37mm
Weight: 1.297kg
ISBN: 9781119976097
ISBN 10: 111997609X
Pages: 688
Publication Date: 14 September 2012
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Dr. Saura C. Sahu, Research Chemist, Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration. Dr. Sahu is the US Editor for the Journal of Applied Toxicology and the editor of Hepatotoxicity (Wiley, 2007), Toxicogenomics (Wiley, 2008), Nanotoxicity (Wiley, 2009), and Handbook of Systems Toxicology (Wiley, 2011).

Reviews for Toxicology and Epigenetics

Despite some of the issues with the structure, Toxicologyand Epigenetics is an important, timely book that providesworld-class, expert opinion on a broad range of topics in a fastmoving highly relevant branch of toxicology. (British Toxicology Society, 1 July 2013)