Toxicologic Pathology

Nonclinical Safety Assessment, Second Edition

Pritam S. Sahota, James A. Popp (Stratoxon LLC, Lancaster, Pennsylvania, USA), Jerry F. Hardisty (Experimental Pathology Laboraties, Inc., Research Triangle Park, North Carolina, USA) , Chirukandath Gopinath (Independent Consultant, Huntingdon, UK)

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English

CRC Press Inc
27 August 2018

Pathology; Medical toxicology; Toxicology (non-medical); Pharmaceutical technology

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk.

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions.

The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.

Edited by: Pritam S. Sahota, James A. Popp (Stratoxon LLC, Lancaster, Pennsylvania, USA), Jerry F. Hardisty (Experimental Pathology Laboraties, Inc., Research Triangle Park, North Carolina, USA), Chirukandath Gopinath (Independent Consultant, Huntingdon, UK), Page Bouchard (Novartis Institute for Biomedical Research, East Hanover, New Jersey, USA)
Imprint: CRC Press Inc
Country of Publication: United States
Edition: 2nd edition
Dimensions: Height: 254mm, Width: 178mm,
Weight: 1.732kg
ISBN: 9781498745307
ISBN 10: 149874530X
Pages: 1244
Publication Date: 27 August 2018
Audience: Professional and scholarly , Undergraduate
Replaced By: 9781032319193
Format: Hardback
Publisher's Status: Active

On page 12

Reviews for Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

...the editors have achieved a truly remarkable feat in pulling together over 70 of the top toxicologic pathologists, the majority of whom are still practicing in their respective fields. This book has much to recommend it to both the experienced toxicologist and toxicologic pathologist and to beginners in the field of drug development. The accumulated knowledge of the contributing authors, much of which has never been published before, makes this a classic that should be in use for many years to come. -John R. Foster, ToxPath Sciences Ltd, Congleton, Cheshire, UK Toxicologic Pathology 2019, Vol. 47(7) 902 Full review available at: https://journals.sagepub.com/doi/pdf/10.1177/0192623319861939 ...the editors have achieved a truly remarkable feat in pulling together over 70 of the top toxicologic pathologists, the majority of whom are still practicing in their respective fields. This book has much to recommend it to both the experienced toxicologist and toxicologic pathologist and to beginners in the field of drug development. The accumulated knowledge of the contributing authors, much of which has never been published before, makes this a classic that should be in use for many years to come. -John R. Foster, ToxPath Sciences Ltd, Congleton, Cheshire, UK Toxicologic Pathology 2019, Vol. 47(7) 902 Full review available at: https://journals.sagepub.com/doi/pdf/10.1177/0192623319861939