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Topics in Modelling of Clustered Data

Marc Aerts Geert Molenberghs Louise M. Ryan Helena Geys

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CRC Press
05 September 2019
Probability & statistics; Mathematical modelling
Many methods for analyzing clustered data exist, all with advantages and limitations in particular applications. Compiled from the contributions of leading specialists in the field, Topics in Modelling of Clustered Data describes the tools and techniques for modelling the clustered data often encountered in medical, biological, environmental, and social science studies. It focuses on providing a comprehensive treatment of marginal, conditional, and random effects models using, among others, likelihood, pseudo-likelihood, and generalized estimating equations methods.

The authors motivate and illustrate all aspects of these models in a variety of real applications. They discuss several variations and extensions, including individual-level covariates and combined continuous and discrete outcomes. Flexible modelling with fractional and local polynomials, omnibus lack-of-fit tests, robustification against misspecification, exact, and bootstrap inferential procedures all receive extensive treatment. The applications discussed center primarily, but not exclusively, on developmental toxicity, which leads naturally to discussion of other methodologies, including risk assessment and dose-response modelling.

Clearly written, Topics in Modelling of Clustered Data offers a practical, easily accessible survey of important modelling issues. Overview models give structure to a multitude of approaches, figures help readers visualize model characteristics, and a generous use of examples illustrates all aspects of the modelling process.
Edited by:   Marc Aerts, Geert Molenberghs, Louise M. Ryan, Helena Geys
Imprint:   CRC Press
Country of Publication:   United Kingdom
Dimensions:   Height: 229mm,  Width: 152mm, 
Weight:   621g
ISBN:   9780367396107
ISBN 10:   0367396106
Pages:   336
Publication Date:   05 September 2019
Audience:   College/higher education ,  Primary
Format:   Paperback
Publisher's Status:   Active

Marc Aerts, Helena Geys, Geert Molenberghs, Louise M. Ryan

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