Theranostic Iron-Oxide Based Nanoplatforms in Oncology: Synthesis, Metabolism, and Toxicity for Simultaneous...

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Mohammad-Nabil Savari Ali Jabali

Theranostic Iron-Oxide Based Nanoplatforms in Oncology

Synthesis, Metabolism, and Toxicity for Simultaneous Imaging and Therapy

Mohammad-Nabil Savari, Ali Jabali

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English

Springer Verlag, Singapore
25 October 2023

Oncology; Medical physics; Biophysics; Nanotechnology

Series: Nanomedicine and Nanotoxicology

This book highlights the most efficient and latest ways to deal with cancer, focusing on IONPs. The book describes some well-designed surface modifications performed through several functional materials over the surface of IONPs, which results in the development of multifunctional IONPs-based delivery nanoplatforms by enhancing solubility, stability, and avoiding side effects on healthy cells. Several types of stimuli-responsive IONPs-based strategies are also discussed. Owing to magnetic, structural, and thermal properties, IONPs themselves can be utilized for magnetic targeting, magnetic hyperthermia, and phototherapy. Significant advancements are presented in IONPs-based immunotherapy, radiotherapy, and sonodynamic therapy for the efficient treatment of cancer. Finally, the book presents RIONs which serve as the parent platform for the development of powerful DMCAs utilized in SPECT/MRI and PET/MRI applications.

By: Mohammad-Nabil Savari, Ali Jabali
Imprint: Springer Verlag, Singapore
Country of Publication: Singapore
Edition: 2023 ed.
Dimensions: Height: 235mm, Width: 155mm,
Weight: 805g
ISBN: 9789819965069
ISBN 10: 9819965063
Series: Nanomedicine and Nanotoxicology
Pages: 410
Publication Date: 25 October 2023
Audience: Professional and scholarly , Undergraduate
Format: Hardback
Publisher's Status: Active

Introduction.- Drug conjugation chemistry in iron oxide nanoparticles (IONPs).- Superparamagnetic iron oxide nanoparticle (SPION) Synthesis.- Properties of Iron oxide nanoparticles (IONPs).- Pharmacokinetics of IONPs.- Magnetic Nanoparticles in Stimuli-Responsive Drug Delivery Systems.- IONPs-based treatment methods.- Diagnosis.- Biosensing.- Bioassays Based on Magnetic Phenomena.- Cytotoxicity/toxicity.- Coatings.- Concluding remarks and future perspectives.

Mohammad-Nabil Savari completed his masters of medical nanotechnology at Tehran Medical Branch, IAU, Tehran, Iran. He had a master's semester in pathogenic microbiology at UT and received his bachelor's degree in biology from SBU. His research is currently focused on designing multifunctional nanoplatforms for multimodal treatment of glioblastoma multiforme. And he asks for cooperation from all researchers in this field. Dr. Ali Jabali, a specialist in medical nanotechnology, obtained his doctorate at Shahid Beheshti University, Iran, and completed a post-doctoral course at the University of Zaragoza, Spain. Currently, he is a member of the academic staff of Tehran Azad University of Medical Sciences, Iran, and he is teaching and researching in the field of nanotechnology. Designing new and engineered nanoparticles is one of his goals, and applying smart nanoparticles is one of his dreams. He is currently working on various national and international projects, and all researchers are invited to cooperate.