The author was born and raised in San Francisco, California. He completed his Bachelor of Science in Chemistry at Stanford University and his PhD in Chemistry at Washington University, St. Louis, under the guidance of Professor Tien-Sung Lin. The author pursued his postdoctoral studies with Professor Richard H. Clarke at Boston University. The author’s independent career began as a chemistry faculty member at West Virginia University in Morgantown, West Virginia. He moved to Loyola University Chicago four years later, where he enjoyed a thirty-four-year sojourn. He is now Professor Emeritus. The author during his time in Chicago wrote two books published by Taylor & Francis: Chemical Thermodynamics and Information Theory with Applications (2011) and Invitation to Protein Sequence Analysis Through Probability and Information (2019). The Thermodynamics of Mathematical Representation is the author’s third book. His hope is that this book will be useful in special topics, classes, and seminars for math/science students and for faculty looking for ideas to incorporate into introductory chemistry, physical chemistry, and calculus classes. The author would have taught the classes and seminars himself, but the pandemic, retirement age, the curse of Zoom©teaching, and the wonderful call to be closer to family in Central New York intervened.