The Sodium-Hydrogen Exchanger

Name: The Sodium-Hydrogen Exchanger
Price: 201.58 AUD
Availability: OutOfStock
ISBN: 9781461350712

From Molecule to its Role in Disease

Morris Karmazyn, Metin Avkiran, Larry Fliegel

$251.95 $201.58

Paperback

Not in-store but you can order this
How long will it take?

Availability Information

We source books from suppliers in Australia and overseas. For books we don't currently have in stock, the time it takes to get them from our suppliers can vary widely - from a few days to a few months - so we check each book with each supplier to determine the expected time it will take to be supplied to us.

We will update you on expected arrival time to us. If this delay is too long, please let us know within 2 business days and we can give you options regarding cancelling or adjusting your order. More details on cancelling your order can be found in our Terms of Trade.

To find out the anticipated arrival time for specific items prior to ordering, please contact us by phone or email:

Phone +61 2 9264 3111, or 1800 4 BOOKS (1800 4 26657) if outside Sydney:
option 1 Abbey's Bookshop (Crime, History, Science, Kids & more) • info@abbeys.com.au
option 2 Language Book Centre (ESL & Foreign Languages) • language@abbeys.com.au
option 3 Galaxy Bookshop (Sci-fi, Fantasy, Romance, Graphic Novels) • sf@galaxybooks.com.au

QTY:

English

Springer-Verlag New York Inc.
30 October 2012

Pharmacology; Cardiothoracic surgery; Organic chemistry; Biochemistry; Cellular biology (cytology)

Summary
Details

I am extremely honored and pleased to have the opportunity to write a few introductory words for this timely volume on Na + /It exchange. This is a field of investigation that I entered into by challenge and necessity, embraced with passion and fmally left in my quest for new discoveries in growth control. Ten years, one third of my scientific life, has been devoted to uncovering the mysteries of intracellular pH (PH;) regulation with respect to growth factor action. I got started on this new topic in 1980, when I heard a rather provocative hypothesis presented by Enrique Rozengurt at an ICN-UCLA Keystone meeting on ""Cell Surface and Malignancy"". He showed that all mitogens induced amiloride-sensitive Na + entry into resting cells and proposed that, if a compound stimulates Na + influx, it could be a mitogen. In support of his proposal Enrique reported that the amphipathic polypeptide, mellitin, which induced Na+ influx, was indeed mitogenic for 3T3 cells. This was only correlation at this stage. However, I was fascinated by this talk. I immediately approached Enrique to inform him of my skepticism about this beautiful story, and to indicate that I would only be convinced when I succeeded in isolating mutant fibroblasts lacking the amiloride-sensitive Na+ transporter. ''Good luck!"" was his response.

Edited by: Morris Karmazyn, Metin Avkiran, Larry Fliegel
Imprint: Springer-Verlag New York Inc.
Country of Publication: United States
Edition: Softcover reprint of the original 1st ed. 2003
Dimensions: Height: 235mm, Width: 155mm, Spine: 18mm
Weight: 539g
ISBN: 9781461350712
ISBN 10: 1461350719
Pages: 317
Publication Date: 30 October 2012
Audience: Professional and scholarly , Undergraduate
Format: Paperback
Publisher's Status: Active